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Epigenetic traces of childhood maltreatment in peripheral blood: a new strategy to explore gene-environment interactions.

Br J Psychiatry

January 2014

Rudolf Uher, MD, PhD, MRCPsych, Dalhousie University Department of Psychiatry, Halifax, Nova Scotia, Canada, and Institute of Psychiatry, King's College London, UK; Ian C. G. Weaver, PhD, Dalhousie University Department of Psychology & Neuroscience, Department of Psychiatry and the Brain Repair Centre, Halifax, Nova Scotia, Canada.

Maltreatment in childhood affects mental health over the life course. New research shows that early life experiences alter the genome in a way that can be measured in peripheral blood samples decades later. These findings suggest a new strategy for exploring gene-environment interactions and open opportunities for translational epigenomic research.

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