Extra-synaptic modulation of GABA and efficacy in bipolar disorder.

Background: Bipolar disorder type I is a severe psychiatric condition that leads to significant morbidity and mortality and whose treatment remains suboptimal. Its pathophysiology involves disturbance in the control of ionic fluxes so that when patients are either manic or depressed, the resting membrane potential of neurons is more depolarized than normal. Available mood stabilizers have a shared mechanism of normalizing ion flux by compensating for ionic abnormalities, and normalizing membrane potential.

Event-Related Potential Study of Executive Dysfunctions in a Speeded Reaction Task in Cocaine Addiction.

This study used a flanker task with NoGo elements to investigate frontal executive function deficits in 19 cocaine abusers. The executive functions of interest in this study were cortical inhibition or ability to withhold motor response, the ability to select an appropriate response among several competing ones, the ability to inhibit inappropriate responses, and the ability to detect error and exercise corrective control. These processes were evaluated with specific frontal and parietal event-related potentials (ERP) registered during performance on this speeded reaction time task with conflicting motor response demands.