Physiological, biochemical, apoptosis-linked gene expression, and histopathological insights in Nile catfish subjected to toxicity by magnetite nanogel.

The target of this novel work is to assess the immunosuppression, genotoxicity, histopathological alterations, and cumulative mortality induced by acute toxicity of magnetite nanogel (MNG) in Nile catfish. Furthermore, a subsequent 10-day depuration period is adopted to estimate the restoration of those disturbed indices. Nile catfish (n = 180) were allotted into four groups and exposed to different concentrations of MNG (0, 1/10, 1/8, and 1/5 96-h LC).

Generation Z in Plastic Surgery: Challenges, Solutions and New Horizons - A European and transatlantic overview.

Introduction:   The entrance of Generation Z (born 1997-2012) into professional life, including the practice of medicine, marks a transformational shift in priorities and values. This generation, shaped by digital immersion and a strong focus on work-life balance, is redefining the landscape of Plastic Surgery. Their preferences for inclusivity, innovation, and structured working hours challenge traditional models of mentorship, patient care, and surgical training.

A Long-term Evaluation: Deep Plane versus High SMAS Face Lift.

In the last few years, the Deep Plane Face Lift (DPFL) has gained great popularity among plastic surgeons, even if its origins are traced back to the 1970s. Certainly, it could have some advantages but based on our experience, it can reveal some unpleasant features in the long term. For this reason, the senior authors have adopted the high superficial musculoaponeurotic system (SMAS) Face Lift for many years in their surgical practice.

Sequential Double-Lung Transplantation In Kartagener Syndrome: A Case Report.

Kartagener syndrome (KS) is a rare congenital disorder, characterized by sinusitis, bronchiectasis and situs inversus. Lung transplantation is an effective treatment for end-stage lung failure, but dextrocardia and differences between hilar structures and pulmonary lobes require adjustments to conventional surgical technique. We present a case of a double-lung transplant without extracorporeal oxygenation in a 48-year-old male patient with KS.

Digital Arteriovenous Malformation. An Uncommon Finding: A Case Report.

Vascular malformations (VMs) are dysplastic abnormalities of vascular channels, differing from vascular tumors by their slow growth. Arteriovenous malformations (AVMs) arise between weeks 4-10 of intrauterine life, with a prevalence of 1 in 100,000 among Caucasians. Common in the head, neck, and hands, AVMs may be asymptomatic or cause symptoms like pain, deformity, and disability.

Epigenetics in Neurodegenerative Diseases.

Healthy brain functioning requires a continuous fine-tuning of gene expression, involving changes in the epigenetic landscape and 3D chromatin organization. Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) are three multifactorial neurodegenerative diseases (NDDs) that are partially explained by genetics (gene mutations and genetic risk factors) and influenced by non-genetic factors (i.e.

Epigenetics in Learning and Memory.

In animals, memory formation and recall are essential for their survival and for adaptations to a complex and often dynamically changing environment. During memory formation, experiences prompt the activation of a selected and sparse population of cells (engram cells) that undergo persistent physical and/or chemical changes allowing long-term memory formation, which can last for decades. Over the past few decades, important progress has been made on elucidating signaling mechanisms by which synaptic transmission leads to the induction of activity-dependent gene regulation programs during the different phases of learning (acquisition, consolidation, and recall).

A DNA phosphorothioation pathway via adenylated intermediate modulates Tdp machinery.

In prokaryotes, the non-bridging oxygen in the DNA sugar-phosphate backbone can be enzymatically replaced by a sulfur atom, resulting in phosphorothioate (PT) modification. However, the mechanism underlying the oxygen-to-sulfur substitution remains enigmatic. In this study, we discovered a hypercompact DNA phosphorothioation system, TdpABC, in extreme thermophiles.

The current landscape of artificial intelligence in oral and maxillofacial surgery- a narrative review.

Objective: This narrative review aims to explore the current applications and future prospects of AI within the subfields of oral and maxillofacial surgery (OMS), emphasizing its potential benefits and anticipated challenges.

Methods: A detailed review of the literature was conducted to evaluate the role of AI in oral and maxillofacial surgery. All domains within OMS were reviewed with a focus on diagnostic, therapeutic and prognostic interventions.

Physiopathological effects of entrance versus distal spread-out Bragg peak on mouse spinal cord neurons.

Recent investigations into radiation-induced side effects have focused on understanding the physiopathological consequences of irradiation on late-responding tissues like the spinal cord, which can lead to chronic progressive myelopathy. Proton therapy, an advanced radiation treatment, aims to minimize damage to healthy tissues through precise dose deposition. However, challenges remain, particularly regarding the variation in dose distribution, characterized by maximum deposition at the end of the proton range, known as the distal fall-off of a spread-out Bragg peak.

Predators drive selection for adaptive plasticity in prey defense behavior.

Plasticity to reduce activity is a common way prey evade predators. However, by reducing activity prey often experience lower individual growth rates because they encounter their own prey less often. To overcome this cost, natural selection should not simply favor individuals generating stronger plasticity to reduce activity rates, but also selection to resume activity once the threat of predation subsides.

Development and current status of anti-reflux esophagogastrostomy after proximal gastrectomy: a literature review.

Background: The selection of an appropriate gastrointestinal (GI) reconstruction procedure after proximal gastrectomy (PG) has long been a challenge. Surgeons have had a long history of exploring anti-reflux gastroesophageal anastomosis. The aim of this article is to systematically summarize the anti-reflux principles of GI reconstructive procedures through a review of the previous literature and to provide a theoretical basis for clinicians to select or innovate procedures.

Reconstruction of a rostral maxillary defect by two custom-made titanium implants following a partial maxillectomy for treatment of squamous cell carcinoma in a dog.

This case report describes the reconstruction of a rostral maxillary defect by two custom-made titanium implants following a rostral partial maxillectomy for treatment of squamous cell carcinoma (SCC) in a seven-year-old dog. An incisional biopsy and CT scan were performed to establish the diagnosis, to plan possible surgery, and to assess the margins of the tumour. The patient had no radiographic signs of metastasis at the time of diagnosis.

Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage.

Up to an estimated 10% of women experience miscarriage in their lifetimes. Embryonic aneuploidy is a leading cause for miscarriage, infertility and congenital defects. Here we identify variants of ELL3, a gene encoding a transcription elongation factor, in couples who experienced consecutive early miscarriages due to embryonic aneuploidy.

Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment.

Growing evidence places the gestational period as a unique moment of heightened neuroplasticity in adult life. In this longitudinal study spanning pre, during, and post pregnancy, we unveil a U-shaped trajectory in gray matter (GM) volume, which dips in late pregnancy and partially recovers during postpartum. These changes are most prominent in brain regions associated with the Default Mode and Frontoparietal Network.

lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke.

Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development. Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).

An assessment of physiological and health responses in Catla catla fingerlings after polystyrene microplastic exposure.

Microplastics (MPs) form when plastic debris is released into the aquatic environment, where they decompose and have deleterious effects on aquatic life. This study aimed to examine the harmful impacts of polystyrene MPs (PS-MPs) on the growth, carcass composition, hematology, digestibility, histopathology, and mineral analysis of Catla catla (11.09 ± 0.

Resin composite aggregated S-PRG particles are not superior to non-S-PRG under microcosm biofilm.

This study assessed the effect of composite resins, aggregated or not with S-PRG particles, and the use of toothpaste in controlling demineralization and bacterial growth. Human molars were distributed into 3 groups: control (CT) - sound teeth, Beautifil Bulk Restorative System (aggregated with S-PRG) (BB), Filtek One Bulk Fill (without S-PRG) (FB). Teeth destined for groups BB and FB previously received Class I preparations (4 × 4 × 4 mm), followed by single-increment restorations.

Serial changes of systemic ventricular function and atrioventricular valve function in patients with failing Fontan.

Objectives: This study investigated the longitudinal changes in ventricular function and atrioventricular valve function to clarify the timing and the mechanisms of failing Fontan.

Methods: Patients who underwent total cavopulmonary connection between 1994 and 2023 were reviewed, and longitudinal echocardiographic examinations of ventricular function and atrioventricular valve regurgitation were analyzed.

Results: A total of 650 patients were included.

Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment.

Adult hippocampal neurogenesis is linked to memory formation In the adult brain, with new neurons in the hippocampus exhibiting greater plasticity during their immature stages compared to mature neurons. Abnormal adult hippocampal neurogenesis is closely associated with cognitive impairment in central nervous system diseases. Targeting and regulating adult hippocampal neurogenesis have been shown to improve cognitive deficits.

Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning.

Lampreys are early jawless vertebrates that are the key to understanding the evolution of vertebrates. However, the lack of cytomic studies on multiple lamprey organs has hindered progress in this field. Therefore, the present study constructed a comprehensive cell atlas comprising 604,460 cells/nuclei and 70 cell types from 14 lamprey tissue samples.

Autologous Micro-Fat Transplantation for Facial Sunken Treatment: Single-Center Experience.

Background: Facial sunken deformities, congenital or acquired, are common in clinical practice for the reduction of soft or hard tissues. In clinical practice, filler injection and tissue transplantation are often used to improve facial contour. Among these, autologous fat grafting for treating facial contour defects is most common in clinical practice.

IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.

Keloid is benign skin tumor, and their curing is relatively difficult due to the unclear mechanism of formation. Inducing ferroptosis of keloid fibroblasts (KFs) may become a new method for treating keloid. Here, we discover interferon (IFN)γ could induce KFs ferroptosis through inhibiting SPOC domain-containing protein 1 (SPOCD1), serving as a mode of action for CD8T cell (CTL)-mediated keloid killing.

Utility of Papilledema for Detection of Elevated Intracranial Pressure in Craniosynostosis.

Papilledema is swelling of the optic disk due to fluid accumulation around the optic nerve and is commonly used to detect increased intracranial (ICP) in craniosynostosis. This study aimed to assess the prevalence and utility of papilledema detection in patients with single-suture, multi-suture, and syndromic craniosynostosis and the differences before and after surgical intervention. A retrospective review of ophthalmology examinations of patients diagnosed with craniosynostosis treated between 2008 and 2023 was performed.

The Role of A Beautiful Appearance in the Redemption of Female Ghosts.

The aim of this study is to analyze the role played by the appearance of female ghosts in their redemption. In the literature on ghosts, entries on female ghosts highlight their "beautiful appearance": Arang (Korean), Otsuyu (Japanese), The White Lady (Europe), Nie Xiaoqian (Chinese), and Maria Makiling (Filipino). Ghosts are women who died tragically, leaving behind unfulfilled desires-particularly those related to romantic or societal expectations such as marriage, love, and motherhood.