1 results match your criteria: "Department of Physiology The University of Arizona Tucson AZ.[Affiliation]"
Article Synopsis
- Abnormal endothelial function in the lungs plays a key role in pulmonary hypertension, with this study focusing on how different sizes of pulmonary arteries (PAs) contribute to this condition.
- It was found that large proximal PAs predominantly rely on nitric oxide release for relaxation, while small distal PAs depend more on a process called endothelium-dependent hyperpolarization (EDH).
- Chronic hypoxia disrupts EDH-mediated relaxation in small distal PAs by downregulating a protein called connexin 40 (Cx40), leading to increased pressure in the right ventricle, which is a significant factor in the development of pulmonary hypertension.