Electro-spun piezoelectric PLLA smart composites as a scaffold on bone fracture: A review.

The intrinsic ability of these scaffold materials to generate piezoelectric currents presents a major proposition for increasing the complexity of the scaffold and facilitating tissue healing. The piezoelectric behavior of bone tissue has been an area of interest for many researchers in the past. However, these properties have not been given much attention in new osteochondral tissue scaffold designs, whereas the established design factors mainly concentrate on the structural and mechanical characteristics of the tissue in question.

Prevascularized Hydrogel Enhancing Innervation and Repair of Full-Thickness Volumetric Muscle Loss in Abdominal Wall Defects.

Current materials for repairing abdominal peritoneal defects face rapid degradation, infection risk, insufficient vascular ingrowth, slow muscle regeneration, and suboptimal postoperative integration, often causing fibrotic healing and hindering volumetric muscle loss (VML) repair exceeding 30%. To address these issues, photo-cross-linkable gelatin hydrogels are combined with blood vessel-forming cells to reconstruct vascular networks, providing temporary nutrient and gas channels that support cell repair. By developing a polymer-chain propagation time technique, hydrogel properties are optimized, avoiding limitations of conventional light exposure.

The effect of nicardipine on the zone of stasis in burns: An experimental rat model.

Background: The zone of stasis in burns is particularly vulnerable to progressive ischemia, making it a critical target for therapeutic interventions. Preventing damage in this zone is essential, as its viability can be preserved with adequate perfusion. Recognizing this, we aimed to investigate the systemic effects of nicardipine, a calcium channel blocker with vasodilatory properties, on the stasis zone in an experimentally induced burn model in rats.

Magnesium-gallate MOF integrated conductive cryogel for inflammation regulation and boosting bone regeneration.

The regeneration and repair of natural bone is a complex and multifaceted process. Potentially, multifunctional scaffolds that exhibit synergistic effects of various biological activities and align with the dynamic bone healing process, are highly expected to achieve desirable bone repairing outcomes. Bioavailable magnesium (Mg) is an essential element taking part in bone regeneration via promoting angiogenesis and osteogenesis.

Encouraging collagen and epithelial layer formation via poly (lactic acid)/hyaluronic acid hybrid wound dressing containing niacinamide.

This study examines the fabrication and characterization of electrospun nanofibrous mats composed of poly (lactic acid) (PLA), hybridized hyaluronic acid (HA), and niacinamide (NA) for potential applications in wound dressings. PLA and HA concentrations were changed from 4 to 12 wt% and 0.25 to 1 wt%, respectively.

A Randomized Controlled Trial Evaluating the Effect of Local Application of Sodium Alendronate Gel and Low-Level Laser Therapy (LLLT) On Peri-Implant Tissue Healing in Wistar Rats.

Objective: To evaluate the effect of local application of Sodium Alendronate incorporated in Carbapol gel together with LLLT on peri-implant tissue healing in Wistar rat femurs.

Methods: Twenty-four male Wistar rats were randomly divided into 4 groups: Group 1 (the control group), Group 2 (the Sodium Alendronate group), Group 3 (the Sodium Alendronate and LLLT group), and Group 4 (the LLLT group). Mini implants were placed in right and left femur bones in all the four groups.

Photo-crosslinking injectable Photothermal antibacterial hydrogel based on quaternary ammonium grafted chitosan and hyaluronic acid for infected wound healing.

Antibacterial hydrogels not only provide a better environment for skin wounds to avoid infection but also accelerate wound healing. Herein, chitosan modified by a quaternary ammonium salt (CQ), and hyaluronic acid grafted with methacrylate (HM) were designed and synthesized to prepare an injectable photo-crosslinking hydrogel for wound dressing with inherent antibacterial and photothermal properties. CQ and HM exhibited excellent biocompatibility, improved water retention, and antibacterial activity, illustrating vast potential as an antibacterial material in various applications.

Adipose-Derived Stem Cell Exosomes Promote Scar-Free Healing of Diabetic Wounds via miR-204-5p/TGF-1/Smad Pathway.

Numerous researches have demonstrated the therapeutic potential of adipose-derived stem cell exosomes (ADSC-Exos) in promoting wound healing. In this study, we aimed to investigate the impact of ADSC-Exos on diabetic wound fibroblasts and elucidate its possible mechanisms. CCK-8, Edu, cell scratch, and Transwell tests were used to evaluate the function of ADSC-Exos on rat skin fibroblasts (RSFs) in high-glucose (HG) medium.

The effect of photobiomodulation therapy on fracture healing: a systematic review and meta-analysis of animal studies.

This systematic review and meta-analysis aimed to evaluate the impact of photobiomodulation therapy (PBMT) on fracture healing in animal models. Following PRISMA guidelines, an electronic search was conducted in PubMed/MEDLINE, Scopus, Embase, and Web of Science databases without date or language restrictions. Animal studies evaluating the effect of PBMT on the healing of complete fractures were included.

[Clinical analysis of 9 cases of paraneoplastic pemphigus with oral damage].

Summarize the clinical characteristics, treatment methods, and prognosis of paraneoplastic pemphigus with oral lesions, and identify commonalities and features to provide better references for the clinical diagnosis and treatment of this disease. A retrospective analysis was conducted on the case data and clinical photos of 9 patients with paraneoplastic pemphigus accompanied by oral lesions treated in the Internal Medicine Ward and Department of Stomatology of Beijing Hospital from September 2017 to December 2023, and the clinical characteristics were summarized and analyzed. All 9 patients had oral mucosal and skin lesions simultaneously, in whom visceral tumors were found upon systemic examinations, including 4 cases of Castleman's disease, 4 cases of thymoma, and 1 case of lung cancer.

Stem Cell Perspective for Regenerative Wound Healing: from Biology toward Future Clinical Directions: A Review.

Chronic wounds, a major clinical challenge, still need to develop new methods based on efficient technologies to improve treatment results. Stem cells, particularly mesenchymal stem cells (MSC), as an advanced approach in skin regenerative medicine, brought new hopes. The multifaceted effects of MSCs, including paracrine signaling, trophic factor secretion, and modulation of the wound microenvironment, orchestrate a cascade of regenerative, plays a critical role in tissue repair.

A Heterojunction Piezoelectric Antimicrobial Asymmetric Hydrogel for Dynamic Wound Healing and Monitoring.

Dynamic wound care presents significant challenges for conventional dressings due to the complex environment and high-frequency motion associated with such injuries. In this study, a multifunctional photo-crosslinked piezoelectric hydrogel (OAPS) is developed, incorporating heterojunction Se-doped KH570 modified BaTiO nanoparticles (Se-BT570 NPs) as a core component, and designed to address antimicrobial and monitoring needs in wound care, particularly at sites with high-frequency movement. The OAPS hydrogel effectively utilizes the inherent high-frequency motion in dynamic wounds, enhancing antimicrobial efficacy and enabling real-time monitoring of wound and human health statuses.

In Operando Locally-Resolved Photophysics in Perovskite Solar Cells by Correlation Clustering Imaging.

The instability of metal halide perovskites limits the commercialization of solar cells despite their impressive efficiencies. This instability, driven by photo-induced ion migration, leads to material restructuring, defect formation, degradation, and defect healing. However, these same "unwanted" properties enable to propose Correlation Clustering Imaging (CLIM), a technique that detects local photoluminescence (PL) fluctuations through wide-field fluorescence microscopy.

Efficacy of fractional laser combined with bipolar radiofrequency in the treatment of atrophic facial acne scaring.

Objective: To evaluate the clinical efficacy of fractional laser treatment combined with bipolar radiofrequency for improving atrophic facial acne scars.

Methods: The clinical data of patients with atrophic facial acne scars treated in the Dermatology Department of The People's Hospital of Chongqing Liangping District from October 2022 to 2023 were retrospectively analyzed. The patients were divided into two groups based on treatment methods: the single intervention group (Group A, n=25) and the combined intervention group (Group B, n=25).

Long-lived photoexcitation probed by photo-induced enhanced Raman spectroscopy: unveiling charge dynamics in Ag-TiO nano-heterojunctions.

This work explores Photo-Induced Enhanced Raman Spectroscopy (PIERS) as a tool to investigate charge carrier dynamics in nanometer-thick Ag-TiO heterojunctions with a Schottky barrier. Due to the light-induced charge transfer process at the semiconductor-metal interface, PIERS provides a significant signal enhancement over traditional Surface-Enhanced Raman Spectroscopy (SERS). In turn, a remarkably stable PIERS signal lasting over 10 days after UVC light illumination cannot be explained exclusively by the presence and the lifetime of the induced oxygen vacancies, so other features of the Ag-TiO heterojunction must be responsible for this effect.

A sesbania gum/γ-polyglutamic acid photo-crosslinking composite hydrogel loaded with multi-component traditional Chinese medicine extract synergizes microenvironment amelioration in infected diabetic wound healing.

The intricate physiological microenvironment of the diabetic wound characterized by overexpressed reactive oxygen species (ROS), persistent inflammation, angiogenetic dysfunction, and bacterial infection impeded the healing process. Herein, a photo-crosslinking composite hydrogel was fabricated based on the methacrylate modification of sesbania gum (SG) and γ-polyglutamic acid (γ-PGA), which could trigger free radical polymerization to form interpenetrating polymer network under 365 nm UV. Meanwhile, the micronized traditional Chinese medicine Huoxue Tongluo extract (HXTL) was encapsulated into the hydrogel to prepare the wound dressing (H-SGPGA).

A multistimuli responsive and self-healing Zn(ii)-inosine supramolecular metal-organic gel: phase selective gelation and application as a light-responsive Schottky barrier diode.

Utilization of naturally available biomolecules such as nucleosides with several coordination sites as organic counterparts for the synthesis of multifunctional self-assembled metal-organic gels is important, considering the time and efforts required for the design of organic ligands that can coordinate to metal ions, forming a gel. In the present work, inosine, a simple nucleoside has been utilized as a ligand for the generation of a supramolecular metallo-hydrogel through coordination with Zn ions in the presence of NaOH. Several spectroscopic, microscopic and rheological investigations have been performed to characterize the formed gel.

Photochemical corneal cross-linking: Evaluating the potential of a hand-held biopen.

The generation of organized 3D tissue constructs that combines cells and photo-crosslinkable biomaterials has been demonstrated using a variety of 3D bioprinting technologies. These technologies have inspired the application for "" bioprinting, resulting on hand-held tools called "Biopens" that can transfer bioprinting capabilities directly into the hands of the surgeons. Here, we have developed and validated a biopen for ophthalmological applications, specifically for corneal stromal regeneration using photochemical corneal crosslinking (CXL), as well as for cell bioprinting and, potentially, for corneal wound healing.

Metal-Phenolic Network (MPN) Modified Janus Fibrous Hydrogel Scaffold for Infected Diabetic Wound Healing.

Management of infected diabetic wounds with large amounts of biofluid is challenging to treat due to localized edema-induced ischemia. Traditional hydrophilic dressings retain wound exudate, raise bacterial infection, and hinder wound healing. Herein, a multifunctional double-layer Janus fibrous hydrogel with a hydrophobic and superhydrophilic potential was designed to accelerate the healing of infected diabetic wounds.

Responsive Magnetic Polymer Nanocomposites through Thermal-Induced Structural Reorganization.

Polymer nanocomposites (PNCs), which feature a hybrid network of soft polymers filled with nanoparticles, hold promise for application in soft robots due to their tunable physiochemical properties. Under certain environmental conditions, PNCs undergo stimuli-responsive structural rearrangement and transform the energy of the ambient environment into diverse uses, for example, repairing the injuries and reconfiguring the shapes of the materials. We develop PNCs with the ability of thermal-responsive restructuring by the stepwise assembly of functional components, including magnetite nanoparticles, silylated cellulose, and polydimethylsiloxane.

Acceptability of telemedicine for early surgical site infection diagnosis after cesarean delivery in rural Rwanda: a qualitative study.

Background: Telemedicine interventions, while promising for enhancing healthcare access, require an evaluation of feasibility and acceptability to inform field implementation. This qualitative study explored the acceptability of a telemedicine intervention in which surgical incision photos taken by community health workers (CHWs) were sent to hospital-based general practitioners to diagnose surgical site infections (SSIs) following cesarean section in rural Rwanda. As the study timeline coincided with the beginning of the COVID-19 pandemic we additionally asked about their perceptions of telemedicine in this context .

Eumelanin pigment release from photo-crosslinkable methacrylated gelatin-based cryogels: Exploring the physicochemical properties and antioxidant efficacy in wound healing.

Managing wounds in certain phases of the healing process still represents a big challenge. The oxidative stress, caused by reactive oxygen species (ROS), is one of the hallmarks controlling the wound healing-related process. Multifunctional biomaterials with excellent biocompatibility, tuneable properties, and easy functionalization, may allow realizing suitable three-dimensional (3D) and extracellular matrix (ECM)-mimicking structures, to efficiently control ROS levels.

The mussel-inspired GelMA/dopamine/hyaluronic acid composite hydrogel dressing for wet surface adhesion.

Tissue adhesives have attracted wide attention as alternatives to sutures. Further developments in adhesives with excellent adhesion and biocompatibility for wet tissue surfaces are still required. This study provides a new solution for the development of bioadhesives for use on tissue surfaces under wet conditions.

Dual oxygen supply system of carbon dot-loaded microbubbles with acoustic cavitation for enhanced sonodynamic therapy in diabetic wound healing.

Diabetic wounds present significant treatment challenges due to their complex microenvironment, marked by persistent inflammation from bacterial infections, hypoxia caused by diabetic microangiopathy, and biofilm colonization. Sonodynamic therapy (SDT) offers potential for treating such wounds by targeting deep tissues with antibacterial effects, but its efficacy is limited by hypoxic conditions and biofilm barriers. To overcome these obstacles, we developed a novel approach using oxygen-carrying microbubbles loaded with Mn-doped carbon dots (MnCDs@OMBs) to enhance SDT and disrupt biofilms.

Fabrication of Hypoxia-Mimicking Supramolecular Hydrogels for Cartilage Repair.

Despite advancements in chronic arthritis treatment, there remains a significant demand for advanced nanotechnologies capable of efficiently delivering a wide range of therapeutic agents to provide symptomatic relief and facilitate the healing of inflamed cartilage tissue. Considering the significant impact of hypoxia on the development and maintenance of chondral tissue, replicating its effects on stem cells could be a potential approach for the treatment of osteoarthritis (OA). Cobalt is a prominent hypoxia-inducing agent, owing to its ability to activate the hypoxia-inducible factor (HIF) pathway regardless of cellular oxygen levels.