1 results match your criteria: "Department of Pharmacology and the Institute for Cell and Developmental Biology[Affiliation]"
Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them.
J Biol Chem
November 2000
Department of Pharmacology and the Institute for Cell and Developmental Biology, SUNY at Stony Brook, Stony Brook, New York 11794-8651, USA.
Article Synopsis
- Phospholipase D (PLD) is involved in various cellular processes like apoptosis and glucose transport, and its activity is regulated by specific activators and repressors.
- Researchers found that PEA-15, a protein that interacts with PLD, not only modifies PLD expression levels but also enhances PLD activity without affecting its enzymatic activation directly.
- The findings indicate that PEA-15 may stabilize PLD proteins, suggesting a significant role in cellular functions related to apoptosis, ERK activation, and glucose transport.