deletion fails to rescue premature lethality in two models of sodium channel epilepsy.

Deletion of , encoding the microtubule-binding protein Tau, prevents disease in multiple genetic models of hyperexcitability. To investigate whether the effect of Tau depletion is generalizable across multiple sodium channel gene-linked models of epilepsy, we examined the mouse model of Dravet syndrome, and the model of Early Infantile Epileptic Encephalopathy. Both models display severe seizures and early mortality.