1 results match your criteria: "Department of Pediatrics and Neonatology Central Clinical Hospital of Ministry of Internal Affairs[Affiliation]"
Behavioral and intellectual functioning in patients with tyrosinemia type I.
Pediatr Endocrinol Diabetes Metab
March 2013
Department of Pediatrics and Neonatology Central Clinical Hospital of Ministry of Internal Affairs, Warsaw, Poland.
Introduction: In tyrosinemia type I (TT1) increased level of tyrosine and phenylalanine (both precursors of neurotransmitters), may potentially influence patients' cognitive development.
Aim Of The Study: Was to evaluate if the children during the treatment with phenylalanine- and tyrosine-restricted diet and nitisinone present with cognitive, emotional or behavioral problems and to find out whether plasma tyrosine and phenylalanine levels may have impact on this.
Material And Methods: Cognitive development and behavior, together with plasma tyrosine and phenylalanine levels, were analyzed in eight patients during their first five years of nitisinone treatment.