2 results match your criteria: "Department of Pediatrics Shimane University Faculty of Medicine Izumo Shimane Japan.[Affiliation]"
Eight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease.
J Am Heart Assoc
November 2024
Department of Regenerative Medicine, Center for Innovative Clinical Medicine Okayama University Hospital Okayama Japan.
Article Synopsis
- A study was conducted to evaluate the long-term effects of Cardiosphere-derived cell (CDC) infusion in patients with single ventricle heart disease, focusing on outcomes over an 8-year period.
- Among 93 patients, those who received CDC infusion experienced a statistically significant reduction in late failure and adverse events compared to control patients, although overall survival rates at 8 years did not significantly differ.
- The beneficial effects of CDC treatment on survival became more apparent by the 4-year mark, particularly for patients with heart failure, suggesting that CDC infusion may provide sustained clinical advantages over time.
Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an autosomal recessive mitochondrial fatty acid oxidation disorder that manifests in three clinical forms: (a) severe, (b) milder, and (c) myopathic. Patients with the myopathic form present intermittent muscular symptoms such as myalgia, muscle weakness, and rhabdomyolysis during adolescence or adulthood. Here, the clinical symptoms and serum creatine kinase (CK) levels of a pregnant 31-year-old woman with the myopathic form of VLCAD deficiency were reduced during pregnancy.
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