7 results match your criteria: "Department of Pediatrics Nippon Medical School[Affiliation]"
Article Synopsis
- Left ventricular noncompaction (LVNC) is a hereditary heart condition marked by unusual heart muscle structure, and this study specifically focused on biventricular noncompaction (BiVNC) in children to understand its clinical characteristics and genetic factors.
- The research involved 234 pediatric patients and revealed that BiVNC often leads to serious complications, including a higher incidence of congenital heart disease and reduced survival rates compared to other heart conditions.
- Findings indicated that patients with BiVNC frequently exhibited left ventricular dysfunction and a notable percentage had genetic variants linked to mitochondrial and developmental issues, emphasizing the need for thorough genetic screening for better patient outcomes.
World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update - XI - Milk supplement/replacement formulas for infants and toddlers with CMA - Systematic review.
World Allergy Organ J
September 2024
Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.
Background: Cow's milk allergy (CMA) is the most complex and common food allergy in infants. Elimination of cow's milk from the diet and replacement with a specialized formula for infants with cow's milk allergy who cannot be breastfed is an established approach to minimize the risk of severe allergic reactions while avoiding nutritional deficiencies. Given the availability of multiple options, such as extensively hydrolyzed cow's milk-based formula (eHF-CM), aminoacid formula (AAF), hydrolyzed rice formula (HRF), and soy formula (SF), there is some uncertainty regarding which formula might represent the most suitable choice with respect to health outcomes.
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- A large-scale study in Japan investigated the link between prenatal factors and congenital heart defects (CHD) in children, focusing on maternal characteristics and behaviors.
- Analyzed data from 91,664 single births, the study found that specific factors such as vitamin A supplement use, certain medications, maternal age, and high hemoglobin levels were significantly associated with an increased risk of CHD.
- The findings highlight the importance of various maternal health aspects during pregnancy and their potential influence on heart defects in children.
Article Synopsis
- The study examines coronary arterial aneurysms (CAAs) in patients with Kawasaki disease (KD), highlighting their impact on patient prognosis and the factors influencing CAA regression.
- Analyzing data from over 1,000 KD patients across 44 institutions in Japan, the research shows that smaller CAAs are more likely to regress over a 10-year period compared to larger ones.
- Key findings indicate that early diagnosis (under age 1), more recent onset of KD (2010-2012), and female sex are linked to higher regression rates for CAAs, which can inform better long-term management strategies for these patients.
Food-dependent exercise-induced anaphylaxis (FDEIA) is a life-threatening but relatively rare disorder which occurs mainly in older children and young adults and manifests with symptoms of anaphylaxis upon exercise following ingestion of certain kinds of food. We herewith report 3 cases of soybean-induced FDEIA. We also highlight 2 types of soybean-induced FDEIA, one caused by storage protein components Gly m 5 and Gly m 6 and the other caused by pollen-related allergen components.
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- Drug resistance in leukemia treatment is linked to abnormal methylation of the topoisomerase II gene, which affects gene expression and drug response.* -
- In this study, researchers analyzed resistant leukemia cells and found that the MX2-resistant cell line exhibited global hypermethylation and alterations in genes related to immunological response and gene silencing.* -
- The study identified p38 mitogen-activated protein kinase as a key player in drug resistance, and inhibiting its activity could potentially restore sensitivity to the drug MX2 in resistant leukemia cells.*