2 results match your criteria: "Department of Pediatrics Johns Hopkins University Baltimore Maryland USA.[Affiliation]"
Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival.
Pulm Circ
April 2023
Division of Pediatric Cardiology, Department of Pediatrics Johns Hopkins University Baltimore Maryland USA.
Article Synopsis
- A proteomic study showed that patients with pulmonary arterial hypertension (PAH) have high levels of insulin-like growth factor binding protein 4 (IGFBP4), especially in connective tissue and idiopathic PAH subtypes.
- Elevated IGFBP4 levels were significantly linked to worsening PAH severity, indicated by lower 6-minute walk distances, higher functional class, and greater right atrial pressures.
- The study identified IGFBP4 as an independent predictor of survival in PAH patients, suggesting that the dysregulation of the insulin-like growth factor axis may impact the disease's progression and severity.
Hepatoma-derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease-associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF levels in a large multicenter cohort (total 2017 adult PAH-Biobank enrollees), we analyzed the associations between HDGF levels and various clinical measures using linear or logistic regression models. Higher HDGF levels were found to be significantly associated with worse pulmonary hemodynamics, prostacyclin treatment; among PAH subtypes, higher HDGF levels were most associated with portopulmonary hypertension (beta = 0.
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