4 results match your criteria: "Department of Pediatrics Jichi Medical University Tochigi Japan.[Affiliation]"
Eight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease.
J Am Heart Assoc
November 2024
Department of Regenerative Medicine, Center for Innovative Clinical Medicine Okayama University Hospital Okayama Japan.
Article Synopsis
- A study was conducted to evaluate the long-term effects of Cardiosphere-derived cell (CDC) infusion in patients with single ventricle heart disease, focusing on outcomes over an 8-year period.
- Among 93 patients, those who received CDC infusion experienced a statistically significant reduction in late failure and adverse events compared to control patients, although overall survival rates at 8 years did not significantly differ.
- The beneficial effects of CDC treatment on survival became more apparent by the 4-year mark, particularly for patients with heart failure, suggesting that CDC infusion may provide sustained clinical advantages over time.
Article Synopsis
- Left ventricular noncompaction (LVNC) is a hereditary heart condition marked by unusual heart muscle structure, and this study specifically focused on biventricular noncompaction (BiVNC) in children to understand its clinical characteristics and genetic factors.
- The research involved 234 pediatric patients and revealed that BiVNC often leads to serious complications, including a higher incidence of congenital heart disease and reduced survival rates compared to other heart conditions.
- Findings indicated that patients with BiVNC frequently exhibited left ventricular dysfunction and a notable percentage had genetic variants linked to mitochondrial and developmental issues, emphasizing the need for thorough genetic screening for better patient outcomes.
Article Synopsis
- Adrenoleukodystrophy (ALD) is a genetic disorder that leads to the degeneration of brain white matter due to mutations affecting the transport of fatty acids, particularly very-long-chain fatty acids (VLCFA).
- The patient in this case was diagnosed with the severe childhood form of ALD at age 5, and although his younger brother tested positive for the same mutation, he showed no symptoms until later imaging indicated brain lesions.
- After receiving unrelated cord blood transplantation, the patient's donor cell levels remained low, yet his neurological condition did not worsen over 7 years, suggesting that even minimal donor cell presence may help prevent disease progression.
Kawasaki Disease With Coronary Artery Lesions Detected at Initial Echocardiography.
J Am Heart Assoc
April 2021
Article Synopsis
- The study examined data from a nationwide survey of Kawasaki disease (KD) patients in Japan, focusing on those with coronary artery lesions (CALs) detected during their initial echocardiography.
- Results showed that 3.6% of patients had CALs, with younger patients (<12 months) and older patients (≥60 months) being more likely to have CALs.
- Delayed hospital visits significantly increased the risk of CAL detection, especially after 7 days of illness, indicating the importance of timely diagnosis and treatment for KD patients.