1 results match your criteria: "Department of Pathophysiology North China Coal Medical College[Affiliation]"
[The effect of NO, ET-1 on brain injury after hind limbs ischemia/reperfusion in rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
February 2005
Department of Pathophysiology North China Coal Medical College, Tangshan 063000, China.
Aim: To study the roles of nitric oxide (NO) and ET-1 in brain injury after hind limbs ischemia/reperfusion in rats and to investigate the effect of NO/ ET-1 balance on brain injury.
Methods: On a model of the hind limbs ischemia/reperfusion (LI/R) of rats, we used L-Arg(L-arginine, L-Arg), one of the substrates in the process of nitric oxide, aminoguanidine (AG) which inhibits nitric oxide synthase(NOS) and ETA receptor antagonist BQ123, to observe the changes of NO, ET-1, MDA, XOD, SOD, LDH in plasma and tNOS, iNOS, cNOS, NO, ET-1, MDA, XOD, MPO, SOD in brain tissue.
Results: Compared with the control group, the content of MDA, XOD, LDH in plasma and MDA, XOD, MPO in brain tissue increased.