3 results match your criteria: "Department of Pathology of North China Coal Medical College[Affiliation]"
[Effect of ERK1/2 signal pathway on the proliferation of lung fibroblast activated by SiO₂].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
August 2010
Department of Pathology of North China Coal Medical College, Tangshan, Hebei Province, China.
Objective: To observe the effect of ERK1/2 signal pathway activated by SiO₂ in the proliferation of human embryonic lung fibroblast mediated by silicotic alveolar macrophages.
Method: The alveolar macrophages (AM) harvested from silicotic sufferers by bronchoalveolar lavage (BAL) were interacted with SiO₂ suspension once more. HELF, pretreated with the inhibitor PD98059 (50 µmol/L) for 1 hour, were stimulated by conditional supernatant fluid of silicotic sufferers.
[Effect of SiO(2) on expression of platelet derived growth factor in human silicotic alveolar macrophages and human embryonic lung fibroblasts].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
April 2009
Department of Pathology of North China Coal Medical College, Tangshan 063000, China.
Article Synopsis
- - The study aimed to investigate how SiO(2) influences the expression of platelet derived growth factor (PDGF) in human alveolar macrophages (AM) and embryonic lung fibroblasts (HELF).
- - Researchers collected AM from a silicotic patient and exposed them to SiO(2) for various durations, then analyzed the PDGF expression in both AM and HELF through various biochemical methods, finding significant increases over time.
- - Results indicated that SiO(2) exposure enhances PDGF expression and collagen synthesis, suggesting a role in the development of lung fibrosis mediated by AM.
[Effect of SiO2 on the expression of MMP-9 and TIMP-1 in human alveolar macrophages in vitro].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
June 2005
Department of Pathology of North China Coal Medical College, Tangshan, Hebei Province 063000, China.
Objective: To study the effect of SiO(2) on the expression of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) in human alveolar macrophages (AMs) associated with the pathogenesis of silicotic fibrosis.
Methods: AMs were collected from a silicotic patient by bronchoalveolar lavage, and exposed to SiO(2) (50 microg/ml), and cultured in DMEM without serum for different time (2, 6, 12, 18, 24, 36 h). Immunocytochemical method was used to detect the level of expression of MMP-9 and TIMP-1 in AMs.