8 results match your criteria: "Department of Pathology University of Miami[Affiliation]"
Association of region-specific hippocampal reduction of neurogranin with inflammasome proteins in brains of Alzheimer's disease.
Alzheimers Dement (N Y)
January 2024
Introduction: Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology.
Methods: We investigated the protein expression, morphological differences of Ng, and correlated Ng to hyperphosphorylated tau in the brains of 17 AD cases and 17 age- and sex-matched controls.
Hand and finger, ultrasound-guided, percutaneous core needle biopsies: A safe procedure with high diagnostic accuracy.
Australas J Ultrasound Med
November 2023
Introduction/purpose: To determine the diagnostic accuracy and complication rates of ultrasound-guided, percutaneous core needle biopsies of soft tissue masses in the hand and fingers.
Methods: Reports from all ultrasound-guided procedures between 21 May 2014 and 17 March 2022 were queried for keywords including "hand", OR "finger", AND "biopsy". Patient demographics, lesion size and location, biopsy needle gauge and the number of cores obtained were recorded.
Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing.
PLoS One
April 2022
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.
Article Synopsis
- Pseudomonas aeruginosa is a hard-to-treat pathogen, particularly in patients with Cystic Fibrosis, and this study tracked multidrug-resistant strains over 17 months in a young CF patient who had a double lung transplant.* -
- Researchers analyzed 22 P. aeruginosa isolates using techniques such as whole genome sequencing and phylogenetic analysis, finding that most strains were resistant to numerous antibiotics and that mutations were accumulating over time, particularly in genes related to DNA repair.* -
- The study highlighted significant genetic diversity among the isolates and identified variations in gene expression related to antibiotic resistance, emphasizing the need for new clinical approaches rather than just relying on single pure cultures for analysis.*
Activity of the growth hormone-releasing hormone antagonist MIA602 and its underlying mechanisms of action in sarcoidosis-like granuloma.
Clin Transl Immunology
July 2021
Section of Pulmonary Miami VA Healthcare System Miami FL USA.
Article Synopsis
- GHRH stimulates growth hormone release, which is important for immune cell growth, but the effects of its antagonist in granulomatous diseases are unclear.
- Research showed expression of GHRH receptors in sarcoidosis tissue and demonstrated that the antagonist MIA602 reduces inflammatory markers in different granuloma models.
- Results suggest MIA602 may be a promising treatment for sarcoidosis by targeting GHRH receptors, showing anti-inflammatory effects without inducing cell death.
Renal sarcoma is a rare and aggressive malignancy without proper guidelines for treatment. Due to the aggressiveness of this disease and the potential for recurrence, we believe that extensive surgical resection with healthy margins may be the best option to treat this condition during both initial resection and resection of the recurrent lesion. Clinical follow-up is also important to monitor for tumor recurrence.
View Article and Find Full Text PDFThe potential role of complements in cocaine-induced thrombotic microangiopathy.
Clin Kidney J
February 2018
Miami Renal Institute, Miami, FL, USA.
Thrombotic microangiopathy (TMA) is a rare disorder characterized by microvascular injury and occlusion resulting in tissue ischemia and dysfunction. TMA occurs in a variety of settings including cocaine use. Although cocaine is widely used in the United States, cocaine-associated TMA is only rarely reported.
View Article and Find Full Text PDFA human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus.
PLoS Negl Trop Dis
June 2017
Department of Pathology University of Miami, Miami, FL, United States of America.
The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation.
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