5 results match your criteria: "Department of Pathology Tokyo Women's Medical University Tokyo Japan.[Affiliation]"

Article Synopsis
  • The BRAF V600E mutation is a resistance mechanism to EGFR-TKIs, highlighted by a case of a 54-year-old Japanese woman with lung adenocarcinoma who developed metastases post-surgery.
  • Despite initial treatment with osimertinib for an EGFR exon 19 deletion, a tumor nodule increased in size after several years of treatment.
  • A switch to dabrafenib and trametinib led to further growth of metastases, suggesting a need for repeated biopsies to understand new gene expressions and the potential benefit of combining treatments rather than switching.
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Mucosa-associated lymphoid tissue (MALT) is a low-grade lymphoma, but cases in which it has transformed into a high-grade lymphoma have been reported, necessitating an accurate diagnosis. The patient was a 79-year-old nonsmoking Japanese female with history of ocular sarcoidosis. A computed tomography scan of her chest revealed a 35-mm nodule in the left S1 + 2, contiguous with the lymph nodes.

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A 69-year-old female Japanese patient presented with an abnormal shadow on chest computed tomography (CT). She had received a mastectomy 14 years prior. Under the diagnosis of primary lung cancer, left upper lobectomy was conducted.

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Pulmonary amyloidosis should be included in the differential diagnosis of calcified lung nodules, and more careful preparation for bleeding should be taken when performing bronchoscopy. While management does not require aggressive treatment, follow-up is necessary to monitor for multiple myeloma and malignant lymphoma.

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We report a rare case of ovarian carcinoma in which a mediastinal recurrence was resected 16 years after the initial operation. A 72-year-old woman underwent hysterectomy with adnexectomy for stage IIIC ovarian serous carcinoma after neoadjuvant chemotherapy. Six courses of adjuvant chemotherapy were administered.

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