4 results match your criteria: "Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee USA.[Affiliation]"
Clinical significance of Philadelphia-like-related genes in a resource-constrained setting of adult B-acute lymphoblastic leukemia patients.
EJHaem
December 2024
Department of Internal Medicine, Hematology Division, Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Faculdade de Medicina University of São Paulo Sao Paulo Brazil.
Article Synopsis
- The text discusses the importance of certain proteins in regulating CXCR4, which is crucial for B-cell movement and function in the germinal center.
- It highlights that the absence of specific genes can lead to abnormal B-cell development, increased mutation rates, and a high risk of developing aggressive B-cell cancers in mice.
- Additionally, the study suggests that these gene deficiencies create a model that mimics human aggressive B-cell lymphomas, offering insights into the mechanisms behind these blood cancers.
Proximally biased V(D)J recombination in the clonal evolution of IGH alleles in BCP-ALL of all age classes.
Hemasphere
April 2024
MLL Munich Leukemia Laboratory Munich Germany.
Herein, we present a rare case of acute myeloid leukemia (AML) with CBFA2T3-rearrangement and the expression of megakaryocytic and lymphoid markers, highlighting the need for a high suspicion index in differential diagnosis and applying adequate workup to avoid misdiagnosing this entity. -positive AML is primarily found in infants with non-down syndrome acute megakaryoblastic leukemia (non-DSAMKL). Flow cytometry immunophenotyping plays an important role in recognizing the unique immunophenotype of bright CD56 expression with dim/negative expression of HLA-DR, CD38, and CD45 termed the RAM immunophenotype in this entity.
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