Mitochondrial myopathies-clinicopathological features and diagnostic modalities.

Mitochondrial myopathy is the term applied to a clinically and biochemically heterogeneous group of disorders which have multisystem involvement. The concept was introduced by Luft in 1962. These are due to genetic defects in the respiratory chain enzymes which are detected by histochemical, immunohistochemical stains, molecular biological studies and ultrastructural studies on muscle biopsy.

Pulmonary pathology in severe malaria infection in health and protein deprivation.

Histopathological changes in the lung resulting from infection with a virulent strain of the malarial parasite, Plasmodium knowlesi, in healthy and protein-deprived Rhesus monkeys were studied. Pertinent changes noted were a high degree of parasitized red cells in septal capillaries, microinfarcts, alveolar and interstitial oedema, interstitial pneumonitis, bronchopneumonia, and injury to septal capillary wall which may be secondary to the production of tumour necrosis factor. These changes were more marked in the non-protein-deprived monkeys.