38 results match your criteria: "Department of Otorhinolaryngology Head and Neck Surgery,Xi'an People's Hospital(Xi'an Fourth Hospital.[Affiliation]"
J Voice
November 2024
Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China; Department of Otorhinolaryngology, Head and Neck Surgery, West China Tian Fu Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China. Electronic address:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
September 2024
Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Cancer Biother Radiopharm
September 2024
Department of Otolaryngology, Hebei Medical University, 050017, Shijiazhuang, China.
Dihydroartemisinin (DHA), an artemisinin derivative, can influence certain malignancies' inflammatory response and growth. This study used Cell Counting Kit-8 and Transwell assays to show that DHA suppressed the growth, migration, and invasion of medullary thyroid cancer cells. Furthermore, the authors used enzyme-linked immunosorbent assay, Western blotting, and immunofluorescence to confirm the expression of the transcriptional coactivators Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ) downstream of the Hippo pathway and changes in the expression of the epithelial-mesenchymal transition (EMT) process markers E-cadherin and N-cadherin.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
July 2024
Department of Otolaryngology & Head and Neck Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.
Autosomal recessive non-syndromic hearing loss (ARNSHL) can cause severe or very severe pre-speech hearing loss. Transmembrane channel-like 1 (TMC1) gene is the sixth deafness gene discovered, but the precise extent of its protein structure and function is unknown. First, history collection, audiology examination and imaging examination were performed on the proband and his family members.
View Article and Find Full Text PDFLin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2024
To investigate the therapeutic effect of laryngotracheal rupture injury and management of related complications. A retrospective analysis was conducted on 10 patients with laryngotracheal rupture injury caused by trauma, admitted between October 2014 and October 2022. Anti-shock treatment, local debridement, tracheal-cricoid cartilage or tracheal-tracheal anastomosis, laryngeal cartilage reduction and fixation, local transposition flaps repair and phase-Ⅱ airway reconstruction were performed respectively on 10 patients.
View Article and Find Full Text PDFCell Death Differ
October 2024
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
The oncogenic potential of chromosome 8q22 copy number gain in liver cancer remains to be depicted. Here, we report that ZNF706, encoded by a gene mapped to chromosome 8q22, is a C2H2-type zinc finger protein. However, the biological function and mechanism of ZNF706 have been poorly investigated.
View Article and Find Full Text PDFMedicine (Baltimore)
May 2024
Department of Head and Neck Thyroid Surgery, Xingtai People's Hospital of Hebei Medical University, Xingtai, P.R. China.
This study aims to dissect the evolution and pivotal shifts in Fine-Needle Aspiration (FNA) research for thyroid nodules over the past 2 decades, focusing on delineating key technological advancements and their impact on clinical practice. A comprehensive bibliometric analysis was conducted on 5418 publications from the Web of Science Core Collection database (2000-2023). Publications were rigorously selected based on their contributions to the advancement of FNA techniques and their influence on thyroid nodule management practices.
View Article and Find Full Text PDFHeliyon
March 2024
Department of Otolaryngology, Head and Neck Surgery, NO.980 Hospital of the Chinese People's Liberation Army Joint Logistics and Security Forces, 050000, Shijiazhuang, China.
Objective: Laryngeal cancer (LC) is one of the most common squamous cell carcinomas of the head and neck in clinical practice, and its incidence has been increasing in recent years, but the prognosis of the patients is not favorable. Hence, it is critical to re-understand and deeply study the causes and mechanisms of LC and explore new effective treatment methods and strategies. In this study, we analyzed the effect of Dihydroartemisinin (DHA) on the pathological progression of LC through the periostin (POSTN)/Yes-associated protein (YAP)/interleukin (IL)-6 pathway, which can provide new clinical references and guidelines.
View Article and Find Full Text PDFAllergy
May 2024
Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2023
Department of Otorhinolaryngology Head and Neck Surgery, Changsha Hospital Affiliated to Hunan Normal University (Changsha Fourth Hospital), Changsha 410006, China.
Clin Cancer Res
August 2023
Department of Biostatistics, Suzhou Zelgen Biopharmaceuticals Co., Ltd, Suzhou, China.
Purpose: The phase II/III study of donafenib was initiated when there was no available treatment indicated for Chinese patients with progressive radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Donafenib, an oral tyrosine kinase inhibitor (TKI), showed good efficacy and tolerability in the phase II study. We aimed to further evaluate the antitumor activity and safety of donafenib in Chinese patients with RAIR-DTC.
View Article and Find Full Text PDFLancet Reg Health West Pac
February 2023
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd., Chengdu, China.
Background: KL-A167 is a fully humanized monoclonal antibody targeting programmed cell death-ligand 1. This phase 2 study aimed to evaluate the efficacy and safety of KL-A167 in Chinese patients with previously treated recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC).
Methods: This was a multicentre, single-arm, phase 2 study of KL-A167 in R/M NPC (KL167-2-05-CTP) (NCT03848286), conducted at 42 hospitals across the People's Republic of China.
Discov Nano
February 2023
Department of Otolaryngology Head and Neck Surgery, Third Xiangya Hospital, Central South University, 138th Tongzipo Road, Yuelu District, Changsha, Hunan, 410013, People's Republic of China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2023
Department of Oncology Plastic Surgery, Hunan Cancer Hospital, Changsha 410008, China.
To investigate the anatomical classification of adductor magnus perforator flap and its application in head and neck reconstruction. From January 2017 to January 2020, Hunan Cancer Hospital treated 27 cases of oral tumor patients (15 cases of tongue cancer, 9 cases of gingival cancer and 3 cases of buccal cancer), including 24 males and 3 females, aged 31-56 years old. The course of disease was 1-12 months.
View Article and Find Full Text PDFBMC Cancer
December 2022
Rutgers University, School of Nursing-Camden, 530 Federal Street, Camden, NJ, 08102, USA.
Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for survival. Preliminary research demonstrated significant associations between structural alternation of mycobiota and PDAC. In this study, we investigated the associations between oral mycobiota and PDAC.
View Article and Find Full Text PDFAuris Nasus Larynx
June 2023
Department of Otolaryngology Head and Neck Surgery, The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital, Shijiazhuang 050000, China. Electronic address:
Objective: Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer, with good prognosis, but the rate of lymph node metastasis (LNM) is high, and the difference between men and women is significant. Therefore, the related risk factors for LNM of PTC based on gender were examined in this study in order to draw attention to gender factor in PTC.
Methods: We retrospectively analyzed the clinicopathological data of 2103 patients with surgically confirmed PTC at the Fourth affiliated Hospital of Hebei Medical University West Side between January 2016 and December 2019.
World J Clin Cases
August 2022
Department of Otorhinolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Taiyuan 030000, Shanxi Province, China.
Background: Relapsing polychondritis is a rare multisystem autoimmune disease that mainly involves systemic cartilage and proteoglycan-rich tissues. If the larynx and trachea are involved, the patient's condition deteriorates rapidly. When relapsing polychondritis becomes more advanced, the airways collapse and treatment is difficult, rendering a poor prognosis.
View Article and Find Full Text PDFZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
August 2022
Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha 410005, China.
J Neuropathol Exp Neurol
September 2022
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hunan Normal University, The Fourth Hospital of Changsha, Changsha, Hunan, P.R. China.
Dexmedetomidine (Dex) is neuroprotective in ischemia-reperfusion (I/R) by suppressing inflammation but the underlying molecular mechanisms are not known. SNW domain-containing protein 1 (SNW1) is a coactivator of the pro-inflammatory transcription factor NF-κB p65. Because SNW1 is regulated by O-GlcNAcylation, we aimed to determine whether this modification influences NF-κB transcriptional activity in neurons undergoing I/R and how Dex may affect the O-GlcNAcylation of SNW1.
View Article and Find Full Text PDFOncol Res Treat
June 2022
Department of Otolaryngology Head and Neck Surgery, the Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital, Shijiazhuang, China.
Background: The objective of this study was to investigate the clinical characteristics, diagnosis, and treatment of inflammatory myofibroblastoma tumor (IMT) in the thyroid gland.
Methods: A total of 17 patients with IMT by pathology from 2010 to 2020 were included in this study. Clinical features, imaging features, treatment, and prognosis were analyzed in this retrospective study.
Exp Brain Res
March 2022
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, P. R. China.
The inflammatory response following spinal cord injury (SCI) involves the activation of resident microglia and the infiltration of macrophages. Activated microglia/macrophages have either detrimental or beneficial effects on neural regeneration based on their functional polarized M1/M2 subsets. Aldose reductase (AR) has recently been shown to be a key component of the innate immune response.
View Article and Find Full Text PDFJAMA Oncol
February 2022
Jiangsu Hengrui Pharmaceuticals Co, Ltd, Shanghai, China.
Importance: Patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) have a poor prognosis and limited treatment options.
Objective: To assess the efficacy and safety of apatinib, a highly selective vascular endothelial growth factor (VEGFR-2) inhibitor, in patients with progressive locally advanced or metastatic RAIR-DTC.
Design, Setting, And Participants: This randomized, double-blind, placebo-controlled, phase 3 trial (Efficacy of Apatinib in Radioactive Iodine-refractory Differentiated Thyroid Cancer [REALITY]) was conducted in 92 patients with progressive locally advanced or metastatic RAIR-DTC between February 17, 2017, and March 2, 2020, at 21 sites within China, and the data cutoff date for this analysis was March 25, 2020.
Mol Med Rep
December 2021
Department of Otolaryngology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Forkhead box (FOX) proteins are multifaceted transcription factors that have been shown to be involved in cell cycle progression, proliferation and metastasis. FOXP4, a member of the FOX family, has been implicated in diverse biological processes in tumor initiation and progression. However, the molecular mechanisms of FOXP4 in laryngeal squamous cell carcinoma (LSCC) remain unknown.
View Article and Find Full Text PDFInt J Cancer
February 2022
Department of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Whether regular fish oil supplementation is associated with cancer risk is controversial. We aimed to evaluate the association of fish oil supplementation on cancer risk according to fatty fish consumption patterns. From the UK Biobank cohort, 470 804 participants with fish oil supplementation data were included.
View Article and Find Full Text PDFCancer Gene Ther
June 2022
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250022, P.R. China.
Immunohistochemical microarray comprising 80 patients with esophageal squamous cell carcinoma (ESCC) and discovered that the expression of CLDN1 and CLDN4 were significantly higher in cancer tissues compared to para-cancerous tissues. Furthermore, CLDN4 significantly affected the overall survival of cancer patients. When two ESCC cell lines (TE1, KYSE410) were exposed to hypoxia (0.
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