[Room tilt illusion: a chief complaint need to be alert in otology clinic].

This study aims to investigated the clinical significance of room tilt illusion（RTI） in screening for central vertigo in otology clinic. A retrospective study of 8 RTI cases out of 656 patients with dizziness and/or vertigo. The characteristics of the symptoms, signs, physical examination, and other examinations of RTI patients were analyzed.

miR-424-5p Promotes Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma.

Background: Recent studies revealed that miR-424-5p regulates the malignant behavior of multiple cancer types. However, the expression and function of miR-424-5p in laryngeal squamous cell carcinoma (LSCC) is unclear.

Purpose: This study aimed to evaluate the association of miR-424-5p level with clinical features of LSCC and investigate the effect and potential mechanism of miR-424-5p on LSCC progression.

Effect of HPV Infection on the Occurrence and Development of Laryngeal Cancer: A Review.

Laryngeal cancer has the second highest incidence of head and neck malignant tumors worldwide. In recent years, studies have shown that human papillomavirus (HPV) infection may be a high-risk factor for laryngeal cancer and closely related to the development and prognosis of laryngeal cancer. The mechanism of the occurrence and development of laryngeal cancer caused by HPV infection needs investigation, as does a rapid and effective HPV detection method for effectively preventing the occurrence of laryngeal cancer and controlling its development.

[How to initially screen common central "malignant vertigo" at the bedside?].

Most of the common dizziness/vertigo diseases in otology clinic are peripheral vertigo diseases, and while about 20% -30% of all vertigo diseases are caused by central nervous system diseases. Pseudo vestibular neuritis, acute ischemic stroke with audiovestibular loss, and central paroxysmal positional vertigo are the three types of central "malignant vertigo" diseases which are most easily misdiagnosed by otologists. This article described the clinical characteristics and bedside physical performance of these three diseases, and summarized the differential diagnosis points for clinical reference.

total flavonoid synergizes cisplatin to inhibit proliferation and enhances the chemosensitivity of laryngeal squamous cell carcinoma.

Laryngeal squamous cell carcinoma (LSCC) is the most common head and neck cancer. extracts play crucial roles in the regulation of cancer progression. However, the role of extracts in LSCC and the related mechanisms remains unclear.

Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1-Binding Proteins in Laryngeal Squamous Cell Carcinoma.

Dysregulation of fascin actin-bundling protein 1 (FSCN1) enhances cell proliferation, invasion, and motility in laryngeal squamous cell carcinoma (LSCC), while the mechanism remains unclear. Here, co-immunoprecipitation and mass spectrometry is utilized to identify potential FSCN1-binding proteins. Functional annotation of FSCN1-binding proteins are performed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis.

Assessment of tumor-associated immune cells in laryngeal squamous cell carcinoma.

Purpose: This study investigated the characteristics of tumor-associated immune cells (TAICs) in laryngeal squamous cell carcinoma (LSCC) and their correlation with clinicopathological variables.

Methods: The immune cell infiltrates of 71 specimens of stages I-IV LSCC were examined. The density of TAICs expressing CD3, CD4, CD8, CD68, and CD163 was assessed using immunohistochemical staining and image analysis in peritumoral and intratumoral regions.

[Analysis of clinical effect of unilateral vidian neurectomy following endoscopic trans-sphenoethmoidal recess approach for allergic rhinitis treatment].

To explore the clinical efficacy of unilateral vidian neurectomy following endoscopic trans-sphenoethmoidal recess approach in treating allergic rhinitis. The clinical data of 80 patients with moderate-severe allergic rhinitis who underwent unilateral vidian neurectomy following endoscopic trans-sphenoethmoidal recess approach were reviewed retrospectively. Visual analogue scale(VAS) was used to assess total symptom scores and nasal symptoms including nasal itching, nasal sneezing, rhinorrhea and nasal congestion.

[Evaluation of curative effect of VNG and VEMP in patients with severe sudden hearing loss].

To evaluate the relationship between vestibular function and curative effect in patients with severe sudden hearing loss.The vestibular function of 79 patients with severe hearing loss was examined by video-nystagmography (VNG) and vestibular evoked myogenic potential (VEMP).There were significant differences between the two test outcomes (<0.

[Nasal irrigation with different concentrations of saline as an adjunctive treatment in allergic rhinitis:A systematic review and Meta-analysis].

To compare the clinical efficacy of different concentrations of saline irrigation in adjuncative treatment of allergic rhinitis by Meta-analysis. According to the inclusion and exclusion criteria, the studies using random controlled trials were retrieved from the Pubmed, Web of science, The Cochrane Library, Embase et al. The Mata-analysis was performed by using RevMan 5.

[A preliminary study of a modified transnasal endoscopic three step vidian neurectomy].

The aim of this study is to explore an improved trans-nasal endoscopic surgical approach for vidian neurectomy. Ninety-one patients with nasal hyperreactive disease were collected, including 49 cases of allergic rhinitis and 42 cases of non allergic rhinitis. All sufferers enrolled in the study have treated with medicine, but the symptoms were not effectively controlled.

[The clinical efficacy of vidian neurectomy and conservative treatment on moderate-severe allergic rhinitis: a Meta-analysis].

To compare the clinical effects of vidian neurectomy with conservative management in the treatment for moderate-severe allergic rhinitis. The studies using case controlled trials which were retrieved from Embase, Pubmed, Web of Science, Cochrane Library etc. The Cochrane risk assessment criteria were used to evaluate the quality of the articles that met the inclusion criteria.

Morphological evaluation using MRI of the olfactory filaments (fila) in a post-traumatic olfactory rat model.

Objective: To investigate whether magnetic resonance imaging (MRI) can be used to directly assess olfactory bulb (OB) lesions and quantify the associated morphological changes of olfactory filaments (OF), also known as fila, in an OB-lesion rat model of the brain.

Methods: A surgical group ( = 5) of male Sprague-Dawley rats was subjected to the unilateral damage of the OB by a steel needle. The control group ( = 5) did not receive surgery.

[Allergic rhinitis management:environment control and patient education].

To observe the auxiliary curative effect of combined clostridium and bifidobacterium capsules, live (also called Changlekang) in the treatment of allergic rhinitis by comparing IL-10, transforming growth factor-β1(TGF-β1), the quality of life score and symptom score before and after oral Changlekang.Twenty qualified patients in the study group and 20 qualified patients in the control group were enrolled.The study group was given changlekang, desloratadine citrate disodium tablets and mometasone furoate nasal spray for treatment.

[Clinical study on serum 25(OH)D level in patients with moderate to severe allergic rhinitis].

Through the detection of the serum 25 (OH) D level of patients with moderate to severe allergic rhinitis (AR), we preliminarily explored the mechanism of vitamin D on AR and provided evidence for the control of AR. Eighty cases of moderate to severe AR and 65 healthy adults were selected as the subjects. The level of 25 (OH) D was detected by enzyme-linked immunosorbent assay (ELISA), and the serum 25 (OH) D level of eight common serum allergens in patients with moderate to severe AR was analyzed.

[Study on the relationship between nasal and eye symptoms and psychological status in patients with allergic rhinitis].

The aim of this study is to analysis the correlation between nasal and eye symptom and psychological status in patients with allergic rhinitis, in order to provide a basis for improving the mental health of patients. The nasal symptom score scale, eye symptom score scale and Kessler 10 were used in the study, and the survey data was analyzed. At least one of 147 patients had a nasal symptom at a rate of 100% (147/147); at least one ocular symptom was 86.

[The expressions and correlations of IL-10, CD14 and CD68 in laryngal squamous cell carcinoma].

The aim of this study is to investigate the distribution of IL-10, CD14 and CD68 in the tumor microenvironment of LSCC with the clinicopathologic factors. We detected the expressions of IL-10, CD14 and CD68 in 46 primary LSCC tumor tissues by immunohistochemistry staining and explore the relationship between them and clinicopathologic factors. We found that the expressions of IL-10, CD14 and CD68 were significantly correlated with clinical stage and T stage (<0.

[A high-precision digital images date set of larynx].

To build a digital cross-sectional images date set of human normal larynx with high-precision.A fresh frozen normal human larynx was embedded using Kawamot's Film Method and then serially sectioned at 10 μm with a LeicaCM3600XP Cryomacrotome, meanwhile digital images of the block surface were recorded after every section with a Nikon D750 camera and stored respectively as JPG and RAW files. All images were cropped to display a constant area on the block surface by photoshop7 and stored as TIFF files.

[The clinical characteristics and treatment strategies of differentiated thyroid carcinoma in adolescents and children].

To investigate the effects of hsa-miR-193b on the proliferation and apoptosis of Hep-2 cells.The experiment was divided into Blank, NC, and miR-193b inhibitor. We used the qRT-PCR to identify the expression of miR-193b in Hep-2 cells.

Sendai Virus Induces Persistent Olfactory Dysfunction in a Murine Model of PVOD via Effects on Apoptosis, Cell Proliferation, and Response to Odorants.

Background: Viral infection is a common cause of olfactory dysfunction. The complexities of studying post-viral olfactory loss in humans have impaired further progress in understanding the underlying mechanism. Recently, evidence from clinical studies has implicated Parainfluenza virus 3 as a causal agent.

[The effects of recombinant human beta-defensin-3 on expression of interleukin-17A and interleukin-22 in BEAS-2B cell].

Objective: To research the effects of recombinant human beta-defensin-3 (hBD-3) on expression of interleukin-17A (IL-17A) and interleukin-22 (IL-22) in BEAS-2B cell.

Methods: The BEAS-2B cells were stimulated with different concentrations of hBD-3 for 6 hours and 24 hours, respectively. Toll-like receptor 2 (TLR2), IL-17A and IL-22 mRNA expression levels were determined by real-time PCR, and the expression levels of IL-17A and IL-22 protein were examined by enzyme linked immune-sorbent assay.

Ubiquitin E3 ligase A20 facilitates processing microbial product in nasal epithelial cells.

Microbial products play a role in the pathogenesis of allergic diseases; ubiquitin E3 ligase A20 (A20) is an important molecule in regulating inflammation in the body. The present study aims to elucidate the role of A20 in processing the absorbed microbial products in nasal epithelial cells. Human nasal mucosal specimens were collected from patients with or without chronic rhinitis and analyzed by immunohistochemistry.