1 results match your criteria: "Department of Orthopedic Surgery Shanghai Changzheng Hospital Naval Medical University[Affiliation]"
Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration.
Mediators Inflamm
October 2024
Department of Orthopedic Surgery Shanghai Changzheng Hospital Naval Medical University, Road No. 415, Fengyang, Shanghai 200003, China.
Article Synopsis
- Intervertebral disc degeneration (IVDD) leads to lower back pain and involves loss of specific cells and degradation of the supporting structure, influenced by factors like inflammation and oxidative stress.
- The glutathione (GSH) redox system serves as a crucial antioxidant in cells, combating oxidative stress by converting harmful substances into less dangerous forms.
- Research highlights GSH's role in various types of cell death linked to IVDD, and exploring small molecule compounds that influence GSH levels could offer new strategies for preventing or slowing IVDD progression.