12,451 results match your criteria: "Department of Orthopedic Dentistry; Uzhgorod National University[Affiliation]"

Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder.

Oral Dis

November 2024

Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea.

Objective: This multicenter cohort study aimed to investigate the impact of antinuclear antibody (ANA) positivity on the malignant transformation potential of oral potentially malignant disorders (OPMDs) using the Observational Health Sciences and Informatics network tools for the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM).

Materials And Methods: Retrospective cohort data from five medical centers were analyzed. Cox regression and 1:4 propensity score matching followed by aggregated meta-analysis were used to evaluate association between ANA positivity and the risk of oral squamous cell carcinoma (OSCC).

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Background And Objective: Iatrogenic spinal durotomies occur at a rate of 1% to 17%. Surgical simulation for durotomy repair is needed to provide affordable, accessible, and validated practice. This study sought to design and validate a simple 3-dimensional printed model for spinal cerebrospinal fluid (CSF) leak repair and to introduce the Rochester original objective structured assessment of technical skills (OSATS) CSF leak (ROCL) repair criteria for assessment.

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Introduction: Regional anaesthesia provides important clinical benefits to patients but is underutilised. A barrier to widespread adoption may be the focus of regional anaesthesia research on novel techniques rather than evaluating and optimising existing approaches. Research priorities in regional anaesthesia identified by anaesthetists have been published, but the views of patients, carers and other healthcare professionals have not been considered previously.

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Non-coding RNAs in oral cancer: Emerging biomarkers and therapeutic frontier.

Heliyon

November 2024

Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Article Synopsis
  • Oral cancer (OC) is a significant global health issue, leading to many deaths, and early detection is vital for better patient outcomes.
  • Advancements in DNA sequencing and transcriptome profiling have highlighted the role of non-coding RNAs (ncRNAs) in regulating genomic processes and signaling pathways, making them promising for clinical use.
  • Combining spatial transcriptomics and metabolomics with single-cell RNA sequencing enhances our understanding of tumor environments, while exploring salivary biomarkers offers non-invasive diagnostic options for OC.
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This study identifies senescent osteocytes in the femur and tibia of young rodents and explores their role in bone remodeling. The proximity of osteoclasts to senescent osteocytes was observed, which is a new finding. Cultured osteocytes, sorted using a podoplanin antibody in FACS, exhibited osteocytic characteristics and increased senescence-related genes.

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Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.

Biomaterials

April 2025

Graduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States; School of Engineering, Brown University, Providence, RI, United States. Electronic address:

Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients' teeth reverting towards their pretreatment positions, which increases the susceptibility to functional problems, dental disease, and substantially increases the financial burden for retreatment. This phenomenon is thought to be induced by rapid remodeling of the periodontal ligament (PDL) in the early stages and poor bone quality in the later stages.

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A rat model for microimplant-assisted rapid palatal expansion.

Biochem Biophys Res Commun

December 2024

Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Center for Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Background: Microimplant-assisted rapid palatal expansion (MARPE) has been widely used to correct maxillary transverse deficiency. To gain valuable insights into the biological processes and mechanisms involved in palatal suture expansion and develop approaches to reduce relapse rates, researchers have turned to animal models. However, no small-animal models are currently available for MARPE.

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Qualitative exploration of 3D printing in Swedish healthcare: perceived effects and barriers.

BMC Health Serv Res

November 2024

Department of Civil and Industrial Engineering, Industrial Engineering and Management, Uppsala University, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 752 37, Sweden.

Background: Three-dimensional (3D) printing produces objects by adding layers of material rather than mechanically reducing material. This production technology has several advantages and has been used in various medical fields to, for instance, improve the planning of complicated operations, customize medical devices, and enhance medical education. However, few existing studies focus on the adoption and the aspects that could influence or hinder the adoption of 3D printing.

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Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.

Eur J Orthop Surg Traumatol

November 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.

Introduction: Intra-articular injections of ozone and hyaluronic acid (HA) are routinely performed for the management of knee osteoarthritis. The present meta-analysis compared intra-articular injections of HA versus ozone in patients with knee osteoarthritis (OA) in patient-reported outcome measures (PROMs). The outcomes of interest were to determine if intra-articular ozone injections show comparable visual analogue scale (VAS) and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) scores compared to intra-articular HA injections.

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Magnesium phosphate-based cements are highly regarded for their bioactive properties, making them excellent candidates as bone substitutes. Despite their promising attributes, challenges such as high reaction temperature, limited injectability, and brittleness limit their application. This study introduces a dual-setting biocomposite cement, which encompasses both cement hydration and hydrogel's cross-linking.

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Objective: The objective of this study is to compare the effect of the location of recombinant human bone morphogenetic protein 2 (rhBMP-2) from the native bone and the periosteum for vertical alveolar bone augmentation.

Materials And Methods: Mandibular, chronic, standardized, bilateral, and vertical defects in 12 beagle dogs were evaluated using four modalities: a xenograft alone (XENO; n = 6); rhBMP-2 alone (BMP; n = 6); a technique with rhBMP-2 close to the host bone covered by xenograft (SAN; n = 6); and a technique with rhBMP-2 close to the flap on top of the xenograft (LAS; n = 6). After 8 weeks, a series of in vivo inspections, fluorescence microscopy, histologic and histomorphometric evaluations, and micro-CT analyses.

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Introduction: A procedural change in the treatment of patients with femoral neck fracture from uncemented to cemented hemiarthroplasty was to be implemented to follow new national guidelines. In accordance with implementation science, it is important to understand the team's thoughts and educational needs. The study aimed to explore surgeons', scrub nurses', anaesthesiologists' and anaesthesia nurses' perceptions of barriers and facilitators to foster a safe educational introduction.

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Accuracy of Cup Alignment in Total Hip Arthroplasty: A Comparison Between Portable Navigation and Goniometer.

Cureus

November 2024

Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JPN.

Article Synopsis
  • Portable navigation systems, like the NAVBIT which uses table tilt registration, can improve accuracy in cup alignment during total hip arthroplasty (THA).
  • A study with 96 patients compared the accuracy of THA using NAVBIT in the lateral position (with the flip technique) versus a cup goniometer in supine or lateral positions.
  • Results showed that the NAVBIT's alignment accuracy (average differences of 2.1° and 2.0°) was significantly better than the cup goniometer’s (average differences of 3.4° and 5.0°), with a higher percentage of cases within 5° of target angles.
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Background: Patients with symptomatic knee osteoarthritis may undergo non-surgical interventions such as intra-articular steroid injections and knee arthroscopy. This study aimed to investigate their association with the timing and outcomes of subsequent primary knee replacement.

Methods And Findings: Observational retrospective analysis of linked Clinical Practice Research Datalink, Hospital Episode Statistics, Patient Reported Outcome Measures (CPRD GOLD-HES-PROMS) data of 38,494 patients undergoing primary knee replacements in England.

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Objectives: To in vitro investigate the effect of different implant surface decontamination methods and treatment storing conditions on implant surface morphology and cell viability.

Materials And Methods: Titanium disks with a sand-blasted and acid-etched surface (Promote, PRO) were treated with diamond polishing brushes (BRUSH), nickel-titanium brushes (NITI), or phenol and sulfuric acid-gel (GEL). The disks were stored in saline (-S) or left exposed to air overnight (-A).

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Introduction: Pediatric Obstructive Sleep Apnea (OSA) is a common sleep-related breathing disorder often linked to distinct craniofacial features and malocclusions. While orthodontic treatments, particularly maxillary expansion and mandibular advancement, have been suggested for managing this condition, the results remain controversial and are based on low-quality evidence. This paper aims to summarize the ongoing debates on this topic by reviewing relevant literature and highlighting the role of the orthodontist in diagnosing and managing OSA in daily clinical practice.

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The growth plate is the primary site of longitudinal bone growth with chondrocytes playing a pivotal role in endochondral bone development. Chondrocytes undergo a series of differentiation steps, resulting in the formation of a unique hierarchical columnar structure comprising round, proliferating, pre-hypertrophic, and hypertrophic chondrocytes. Pre-hypertrophic chondrocytes, which exist in the transitional stage between proliferating and hypertrophic stages, are a critical cell population in the growth plate.

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Article Synopsis
  • A review of cadaver studies was conducted to evaluate the decrease in compressive strength after surgery, adhering to PRISMA guidelines while utilizing databases like PubMed and Google Scholar.* -
  • Out of the five studies involving 49 cadavers, one study found a statistically significant decrease in force leading to fracture (FLF) in decancellated tibias compared to the healthy ones, with a mean FLF of 3766.9 N versus 5126.4 N.* -
  • Although most FLF values in the studies were significantly above the body weight threshold for safety, some cadavers recorded FLF below this threshold, suggesting that while weight-bearing after the procedure seems statistically acceptable, clinical safety cannot be universally
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Achieving bone union remains a significant clinical dilemma. The use of osteoinductive agents, specifically bone morphogenetic proteins (BMPs), has gained wide attention. However, multiple side effects, including increased incidence of cancer, have renewed interest in investigating alternatives that provide safer, yet effective bone regeneration.

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Article Synopsis
  • This study compared the outcomes of cementless versus cemented fixation in total knee arthroplasty, focusing on factors like infection rates, revision needs, operation time, and function scores.
  • It included 16 randomized controlled trials with 2,358 participants and found no significant differences in infection, loosening, or revision rates between the two methods.
  • However, cementless fixation showed better knee function scores in follow-ups under 5 years, while cemented fixation had better scores after 5 years, and cementless procedures required less operation time.
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Mandibular Reconstruction Utilizing the Reamer-Irrigator-Aspirator to Obtain Nonvascularized Femur Grafts.

J Oral Maxillofac Surg

November 2024

Resident, Division of Oral & Maxillofacial Surgery, Department of Surgery, University of Cincinnati, Cincinnati, OH; Assistant Professor of Surgery, Division of Oral & Maxillofacial Surgery, Department of Surgery, University of Cincinnati, Cincinnati, OH. Electronic address:

Between July 2021 and February 2024, 6 patients with biopsy-confirmed benign pathologic lesions had mandibular defects reconstructed using a reamer-irrigator-aspirator at the University of Cincinnati Medical Center. Patients' ages ranged from 34 to 73, 5 of which were males and one female. Primary end points were bony continuity of the mandible, recovery time, and ability of the graft to receive implants.

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Autologous Peripheral Blood-Derived Orthobiologics for the Management of Shoulder Disorders: A Review of Current Clinical Evidence.

Pain Ther

February 2025

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.

Introduction: A multidisciplinary approach is recommended to manage shoulder pain, the third most common musculoskeletal disorder, but traditional modalities have limitations, providing only temporary symptomatic pain relief instead of targeting the underlying pathophysiology. Recently, autologous peripheral blood-derived orthobiologics (APBOs) have become popular for the management of shoulder disorders. Platelet-rich plasma (PRP) is the most frequently used APBO, but its efficacy remains disputable.

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Platelet-rich plasma: A bibliometric and visual analysis from 2000 to 2022.

Medicine (Baltimore)

November 2024

Department of Pain Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People's Republic of China.

Background: Platelet-rich plasma (PRP) is an integral biotherapeutic modality with evolving significance in the medical domain. Despite its expanding applications, a comprehensive bibliometric evaluation is essential to understand its development and impact.

Methods: The Web of Science core collection subject search identified articles pertinent to PRP applications.

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Changes Over Time in Masseter Muscle Activity, Symptoms of Discomfort, Stress Level and Salivary Flow Rate Following Intra-Oesophageal Acid Infusion.

J Oral Rehabil

November 2024

Department of Orthodontics and Dentofacial Orthopedics, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Background: Intra-oesophageal acid stimulation increases masseter muscle activity. However, the infusion speeds used in previous studies are significantly slow, with minimal acid volume (30 mL over 30 min). Additionally, it is unclear how masseter muscle activity, symptoms of discomfort, stress levels and saliva quantity change over time.

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