Extracellular heat shock protein 72 protects schwann cells from hydrogen peroxide-induced apoptosis.

The cytoprotective role of extracellular heat shock protein (Hsp) 72 has been demonstrated in various cell types, including neuronal cells; however, few studies have investigated the actual role of Hsp72 in the survival of Schwann cells (SCs). In the present study, we investigated the effect of exogenous Hsp72 on Schwann cell apoptotic cell death induced by H₂O₂. We determined that extracellular exposure to Hsp72 reduced cell death in rat SCs in a dose-dependent manner, with the protection resulting from downregulation of apoptosis induced by H₂O₂ (as shown by TUNEL and annexin V flow cytometry analyses).

[Application of damage control orthopaedic for the treatment of comminuted fractures of superior tibia in complex injury].

Objective: To investigate the treatment of comminuted superior tibial fracture in complex injury according to damage control orthopaedic.

Methods: From Jan. 2007 to Jun.

Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells.

Oxidative stress is one of the several mechanisms that induces apoptosis in cells. It has been shown that hydrogen peroxide (H(2)O(2)) induces apoptosis in several kinds of cells; however, the role of H(2)O(2) in the apoptosis of Schwann cells (SCs) is currently unclear. The objective of this study was to determine whether H(2)O(2) is capable of inducing apoptosis in SCs and whether or not such an effect is associated with the activation of mitochondrial pathway.