Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.

Purpose: To assess the efficacy of topical interferon α-2β(IFN) eye drops as a primary treatment for ocular surface squamous neoplasia(OSSN) and evaluate factors that impact response to treatment and recurrence of OSSN.

Method: A retrospective study of 143 OSSN patients treated with topical IFN(1MIU/ml) from January 1998 to June 2021. The diagnosis was based on clinical examination and anterior segment optical coherence tomography, with histologic confirmation was present in 46.

Conjunctival papilloma treatment outcomes: a 12-year-retrospective study.

Background: Conjunctival papilloma is often resistant to treatment. Various therapies have been reported with no gold standard. The purpose of this study was to compare treatment outcomes after various therapies.

Nocardia keratitis: amikacin nonsusceptibility, risk factors, and treatment outcomes.

Purpose: To report the increasing trends in Nocardia keratitis species diversity and in vitro antibiotic susceptibility, to demonstrate contact lens wear as a risk factor, and to report visual acuity outcomes after treatment.

Methods: A retrospective clinical case series was performed at a single academic referral center which identified 26 patients with culture-confirmed Nocardia keratitis between 2014 and 2021. A combination of conventional microbiology and molecular techniques were used to identify isolates.

The role of imaging technologies for ocular surface tumors.

Purpose Of Review: This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.

Recent Findings: HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings.

A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS).

Introduction: We propose a minimum data set framework for the acquisition and analysis of retinal images for the development of retinal Alzheimer's disease (AD) biomarkers. Our goal is to describe methodology that will increase concordance across laboratories, so that the broader research community is able to cross-validate findings in parallel, accumulate large databases with normative data across the cognitive aging spectrum, and progress the application of this technology from the discovery stage to the validation stage in the search for sensitive and specific retinal biomarkers in AD.

Methods: The proposed minimum data set framework is based on the Atlas of Retinal Imaging Study (ARIAS), an ongoing, longitudinal, multi-site observational cohort study.

Blood flow studies and serological testing in the diagnostic evaluation of glaucoma: a pilot study.

Background And Objective: To evaluate the prevalence of hemodynamically significant carotid artery stenosis, peripapillary blood flow, and serologic abnormalities in a pilot study among patients with glaucoma.

Patients And Methods: All subjects underwent complete eye examination, standard automated perimetry, carotid Doppler ultrasonography, serum laboratory testing, and scanning laser Doppler flowmetry (SLDF). Subjects were subdivided into two groups based on glaucoma subtype (normal-tension vs primary open-angle glaucoma) and severity (mild vs moderate-advanced).

The spectral reflectance of the nerve fiber layer of the macaque retina.

This paper reports the first quantitative measurements of the reflectance spectrum of the nerve fiber layer (NFL) of the retina. An arcuate defect in the NFL of two macaque monkeys was produced by photocoagulating a small spot near the optic disc. Imaging fundus reflectometry at 8 wavelengths was then used to measure the fundal reflectances in the defect and in the intact NFL.