12 results match your criteria: "Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan.[Affiliation]"
Article Synopsis
- Decidualization is crucial for successful embryo implantation, and failures in this process can lead to issues like miscarriage; the extent of decidualization failure in infertile women is not well understood.
- Researchers analyzed endometrial samples from 33 infertile women in the late-secretory phase to determine the prevalence of decidualization failure and examined key transcription factors related to the process.
- Findings showed that 62.5% of the women experienced decidualization failure, which was linked to a history of more miscarriages, and notable differences in the expression levels of important transcription factors were observed between those with and without failures.
Purpose: To investigate whether long noncoding RNAs (lncRNAs) are involved in the development or malignant behavior of ovarian high-grade serous carcinoma (HGSC), we attempted to identify lncRNAs specific to HGSC.
Methods: Total RNAs were isolated from HGSC, normal ovarian, and fallopian tube tissue samples and were subjected to a PCR array that can analyze 84 cancer-associated lncRNAs. The lncRNAs that were upregulated and downregulated in HGSC in comparison to multiple samples of normal ovary and fallopian tube were validated by real-time RT-PCR.
Purpose: We investigated the interactions between mural granulosa cells (MGCs) and cumulus granulosa cells (CGCs) during ovulation after the LH surge.
Methods: We performed clustering, pseudotime, and interactome analyses utilizing reported single-cell RNA sequencing data of mouse ovary at 6 h after eCG-hCG injection.
Results: Clustering analysis classified granulosa cells into two distinct populations, MGCs and CGCs.
Purpose: To test the theory that invaginated ovarian surface epithelium and endometrial implants on the ovary form ovarian endometriomas.
Methods: Adhesion sites of ovarian endometrioma on the peritoneum and consecutive ovarian endometrioma cyst wall, called non-adhesion sites, were histologically examined. DNA methylomes of the adhesion sites, non-adhesion sites, and blueberry spots were compared with those of ovary, endometrium, and peritoneum.
Purpose: We investigate the relationships between oocyte developmental capacity and follicular size of its origin in Japanese women: those undergoing conventional IVF (cIVF) and ICSI, respectively.
Methods: A total of 3377 follicles were punctured separately and were classified into three groups (large, medium, and small) by their diameters. A total of 1482 retrieved oocytes were individually cultured and received cIVF or ICSI.
Article Synopsis
- - The study aimed to find long non-coding RNAs (lncRNAs) that are expressed unusually in ovarian high-grade serous carcinoma (HGSC) by analyzing RNA from various ovarian cell types.
- - Using a PCR array, researchers pinpointed ten lncRNAs with altered expressions in HGSC cell lines—six were upregulated and four downregulated—and tested their effects on cell activities like proliferation, migration, and apoptosis.
- - They discovered that overexpressing certain lncRNAs (MEG3 and POU5F1P5) inhibited cell migration, and the same four downregulated lncRNAs were also found to be low in actual HGSC tissue samples, indicating their potential significance in ovarian cancer.
Purpose: Clomiphene citrate (CC) has been used as a first-line treatment for anovulatory polycystic ovary syndrome (PCOS). However, some patients with PCOS are resistant to standard CC treatment. In this study, a new CC treatment protocol was developed, named "intermittent CC treatment" (ICT) and its efficacy was investigated on the induction of follicular growth in patients with PCOS who were resistant to standard CC treatment.
View Article and Find Full Text PDFPurpose: Carbonyl reductase 1 (CBR1) is involved in cancer progression. Recently, the authors reported that the loss of CBR1 expression is associated with a poor prognosis in uterine cervical cancer. Here, we investigated whether the decreased CBR1 expression promotes cancer progression by inducing the epithelial mesenchymal transition (EMT).
View Article and Find Full Text PDFPurpose: Prenatal exposure to environmental chemicals is a growing concern, because such exposures have been shown to be associated with various diseases. The levels of chemicals and heavy metals in maternal blood, cord blood, maternal urine and amniotic fluid in Japanese pregnant women were investigated.
Methods: A total of 145 women, including 14 fetal growth restriction cases, were included in the present study.
Article Synopsis
- A study in Japan examined how adenomyosis affects pregnancy complications and outcomes by surveying 725 medical facilities.
- The research included data from 272 pregnant women with adenomyosis, identifying complications such as miscarriages, preterm deliveries, and hypertension, without significant differences based on treatment types.
- Findings suggest that larger and diffuse adenomyosis is linked to worse pregnancy outcomes, with increased risks of hypertension and infections in those with the diffuse type.
Aim: A multicenter, retrospective survey was conducted in order to investigate the current clinical status of adenomyosis in Japan.
Methods: The questionnaires covered the management of infertile women with adenomyosis and the outcomes of infertility treatment in women with adenomyosis. The questionnaires were sent to 1149 facilities in Japan.
Aim: Although a thin endometrium has been well recognized as a critical factor in implantation failure, little information is available regarding the molecular mechanisms. The present study investigated these mechanisms by using genome-wide mRNA expression analysis.
Methods: Thin and normal endometrial tissue was obtained from a total of six women during the mid-luteal phase of the menstrual cycle.