5 results match your criteria: "Department of Obstetrics and Gynecology Kansai Medical University Osaka Japan.[Affiliation]"
Article Synopsis
- The study examines the expression and role of NDRG1 in the human ovary, which is linked to cellular processes like growth and oxygen sensing but is not well understood in this context.
- Follicular fluid and luteinized granulosa cells were analyzed for NDRG1 levels, revealing a positive correlation between NDRG1 and other important factors like VEGF and progesterone during stress conditions induced by cobalt chloride.
- Findings suggest that NDRG1 is crucial for follicular development and early luteinization, with its expression being influenced by hypoxic conditions and modulated by treatments like echinomycin.
Background: Ovarian function is closely related to the degree of vascular network development surrounding the ovary. Maternal aging-related construction defects in this vascular network can cause ovarian hypoxia, which impedes oocyte nutrient supply, leading to physiological changes in the ovaries and oocytes. The anti-aging gene Sirtuin 1 (SIRT1) senses and adapts to ambient stress and is associated with hypoxic environments and mitochondrial biogenesis.
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- The study investigates how cigarette smoke affects the maturation of the endometrium, which is crucial for reproductive health, by looking at its impact on human endometrial stromal cells (ESCs).
- Researchers cultured ESCs with different concentrations of cigarette smoke extract (CSE) and hormones to assess changes in cell behavior and specific gene expressions.
- Results indicate that higher concentrations of CSE hinder cell growth and induce cell death, while lower concentrations affect the expression of factors related to blood vessel formation and hormonal signaling, ultimately suggesting that smoking negatively impacts endometrial development.
Purpose: Resveratrol is a well-known potent activator of sirtuin-1 (SIRT1). We investigated the direct effects of hypoxia and resveratrol on SIRT1/ peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) pathways, vascular endothelial growth factor (VEGF), hypoxia-inducible factor (HIF)-1α, and mitochondrial quantity in a steroidogenic human ovarian granulosa-like tumor cell line (KGN) cells.
Methods: KGN cells were cultured with cobalt chloride (CoCl; a hypoxia-mimicking agent) and/or resveratrol.
Background: Decidualization of the human endometrium, which involves a dramatic morphological and functional differentiation of human endometrial stromal cells (ESCs), is essential for the establishment of a successful pregnancy. Decidualization results from a complex interplay of transcription factors, morphogens, cytokines, cell cycle regulators, and signaling pathways.
Methods: Based on a literature review, the regulation of, and the molecular mechanisms involved in, the decidualization of the endometrium are described.