Psychometric Properties of the Self Care Oral Anticancer Agents Index (SCOAAI).

Objective: To test the Self-Care Oral Anticancer Agents Index (SCOAAI)'s psychometric properties (structural validity, convergent validity, predictive validity, and internal consistency) in a sample of patients with solid tumour on Oral anticancer agents (OAA).

Methods: A methodological research in five in- or out-patient Italian facilities. Structural validity was tested by confirmatory factor analysis, and internal consistency was assessed through Cronbach's alpha and composite reliability.

Maternal and neonatal outcomes after metabolic and bariatric surgery among women with severe obesity.

Background: Earlier evidence indicated that metabolic and bariatric surgery (MBS) may adversely affect neonatal outcomes among patients conceiving soon after MBS, but recent studies demonstrated conflicting results, especially for new surgical techniques.

Objectives: The aim of this study was to assess the effects of MBS types and surgery to birth interval on maternal, birth, and nonbirth outcomes in women with severe obesity.

Setting: New York State's all-payer hospital discharge database (2008-2019).

Healthy lifestyle before and during pregnancy to prevent childhood obesity: study protocol for a parallel group randomised trial - the PRE-STORK trial.

Introduction: The global prevalence of people living with overweight has tripled since 1975 and more than 40% of Danish women enter pregnancy being overweight. With the increasing rates of obesity observed in children, adolescents and adults, there is an urgent need for preventive measures. Risk factors for childhood obesity include maternal overweight or obesity before conception and excessive weight gain during pregnancy.

Association of statins use and genetic susceptibility with incidence of Alzheimer's disease.

Background: The effect of statins use on the incidence of Alzheimer's disease (AD) is still under debate, and it could be modified by a series of factors.

Objectives: We aimed to examine the association of statins use with the risk of cognitive impairment and AD, and assess the moderating roles of genetic susceptibility and other individual-related factors.

Design: A longitudinal study was conducted from the UK Biobank where individuals completed baseline surveys (2006-2010) and were followed (mean follow-up period: 9 years).

Introducing and establishing birth companionship in labour ward of a tertiary care centre in North India: a quality improvement journey through and beyond COVID-19 pandemic.

Background: Allowing a birth companion is the basic right of a mother and is identified as an important component of respectful maternity care. The implementation of this intervention has been a challenge in heavy-load public health facilities in India.

Local Problem: Despite the proven benefits of the presence of birth companions on maternal-fetal outcomes, there was no policy of allowing birth companions in our hospital.

Downregulation of the Phosphatase PHLPP1 Contributes to NNK-induced Malignant Transformation of Human Bronchial Epithelial Cells (HBECs).

Cigarette smoking (CS) is one of the greatest health concerns, which can cause lung cancer. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, and has been well-documented for its carcinogenic activity in both epidemiological and laboratory studies. PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and phosphatase and tensin homolog (PTEN) are two well-known phosphatase tumor suppressors that have been reported to be downregulated in human lung cancer tissues.

Menstrual cycle characteristics across the reproductive lifespan and cognitive function in midlife women.

Background: Menstrual cycle characteristics are potential indicators of hormonal exposures and may also signal cardiovascular disease risk factors, both of which are relevant to cognitive health. However, there is scarce epidemiological evidence on the association between cycle characteristics and cognitive function.

Objectives: We studied the associations of menstrual cycle characteristics at three stages of a woman's reproductive lifespan with cognitive function in midlife.

Racial and ethnic enrollment disparities in clinical trials leading to FDA approvals for gynecologic malignancies.

Background: Black women and other minorities have higher age adjusted incidence risk for cervical and endometrial cancer than White women. However, the extent of racial and ethnic disparities in clinical trial enrollment among studies performed mainly in North America and Europe for gynecologic malignancy is unknown.

Objective: This study analyzed enrollment rates by race/ethnicity in trials that led to Food and Drug Administration (FDA) approvals for gynecological cancers from 2010 to 2024.

CXCR4 antagonist-loaded nanoparticles reprogram the tumor microenvironment and enhance immunotherapy in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a leading cause of cancer death that has limited treatment options for advanced stages. Although PD-1 inhibitors such as nivolumab and pembrolizumab have been approved for advanced HCC treatment, their effectiveness is often hampered by the immunosuppressive tumor microenvironment (TME), which is due to hypoxia-driven CXCL12/CXCR4 axis activation. In this study, we developed 807-NPs, lipid-coated tannic acid (TA) nanoparticles that encapsulate BPRCX807, a potent CXCR4 antagonist to target HCC.

Treatment for anxiety, depression, and stress in pregnant people experiencing antepartum hospitalization: a systematic review and meta-analysis.

Objective: To systematically evaluate inpatient interventions to reduce symptoms of anxiety, depression, or stress in pregnant individuals during antepartum hospitalization.

Data Sources: Searches were conducted in Ovid MEDLINE, Embase, CINAHL Plus, Cochrane CENTRAL, and PsycINFO from database inception through April 2023.

Study Eligibility Criteria: Randomized controlled trials and cohort studies were eligible for inclusion if an intervention was compared to treatment as usual (TAU) to reduce symptoms of anxiety, depression, or stress among pregnant individuals admitted to a hospital's antepartum unit.

Cumulative effects of extreme ambient temperatures on placental perfusion and function markers in early pregnancy: analysis from a birth cohort study.

Background: Exposure to suboptimal temperatures during pregnancy has been associated with adverse pregnancy and birth outcomes related to placental development disorders. No prior studies have examined the potential impacts of temperature on placental markers. We conducted an investigation into the cumulative impact of daily ambient temperature on critical clinical placental perfusion and function markers during the placentation period, utilizing data from a prospective birth cohort in Nanjing, China.

Association of willingness to use hormonal contraception with knowledge: a national survey.

Objective: To determine if willingness to use and concern with using hormonal contraception (HC) is associated with knowledge about HC.

Study Design: We conducted an online cross-sectional survey of self-identified women, US residents 18 and older using Amazon Mechanical Turk and ResearchMatch.org.

Long-lived cytokinetic bridges coordinate sister-cell elimination in mouse embryos.

Apoptosis is a key feature of preimplantation development, but whether it occurs in a cell-autonomous or coordinated manner was unknown. Here, we report that plasma membrane abscission, the final step of cell division, is profoundly delayed in early mouse embryos such that a cytokinetic bridge is maintained for the vast majority of the following interphase. Early embryos thus consist of many pairs of sister cells connected by stable cytokinetic bridges that allow them to share diffusible molecules.

Characterization of senescence-associated transcripts in the human placenta.

Introduction: Fusion of mononucleated cytotrophoblasts into syncytium leads to trophoblast senescence. Yet, premature senescence is associated with preeclampsia, fetal growth restriction (FGR), and related obstetrical syndromes. A set of 28 transcripts that comprise senescence-associated secretory phenotype (SASP) was recently described in placentas from women with preeclampsia.

The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer.

T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors. The chemokine CX3CL1 recruits tumour-suppressive T-cells into solid tumours, but also mediates cell-cell adhesions, e.g.

Abortion provision and characteristics of abortion patients in an academic medical center in Washington state before and after Dobbs.

Objective: To examine abortion care in the largest academic medical center in Washington, a state protective of abortion rights, before and after the Supreme Court Dobbs decision.

Methods: This retrospective cohort study evaluated abortion provision at the University of Washington between January 1, 2022 and October 31, 2023. Data on patient sociodemographic and clinical characteristics were extracted from electronic medical records.

Post-Kasai cholangitis evaluation and management strategies: Review of the literature with insights from the Swiss Biliary Atresia Registry.

Cholangitis, defined as the inflammation of the bile ducts, is the most frequent complication after Kasai hepatoportoenterostomy in patients with biliary atresia (BA). This review seeks to provide a comprehensive synthesis of current knowledge on diagnosing and managing BA-associated cholangitis while identifying gaps in the existing literature. A scoping literature review was conducted to gather global insights into the definition, evaluation, and management of post-Kasai cholangitis, illustrated through data from the Swiss Biliary Atresia Registry (SBAR).

Incidental finding of didelphys uterus with twin pregnancy in each cavity; A rare case report.

Introduction And Importance: Uterine didelphys is a Müllerian duct anomaly with two uteri and cervices, with or without a vaginal septum. A di-cavitary twin pregnancy in a uterus didelphys is an infrequent occurrence.

Case Presentation: A 27-year-old woman, gravida 3, para 2, at a gestational age of 37 weeks and 4 days, presented with pushing-down pain.

Carcinosarcoma of the fallopian tube: A rare case with rapid metastases and port-site metastasis.

Introduction And Importance: Fallopian tube cancer, particularly the carcinosarcoma subtype, is a rare malignancy posing diagnostic challenges.

Case Presentation: Our patient was an 83-year-old, nulligravida woman, presented to our outpatient clinic with one month of pelvic pain. On examination, a pelvic mass was detected.

Analysis of pathogen distribution, drug sensitivity and inflammatory indicators related to pelvic infection after hysterectomy.

Objective: To analyse the distribution of pathogens, risk factors and inflammatory indicators related to pelvic infection after hysterectomy.

Methods: Patients who underwent hysterectomy at Women's Hospital of Nanjing Medical University between January 2022 and January 2023 were recruited into this study. Vaginal secretions from patients with suspected postoperative pelvic infection were collected for pathogen cultivation, identification, and antimicrobial susceptibility analysis.

Radiological evaluation of pelvic venous Disorders: A comprehensive review.

Pelvic venous disorder (PVD) is a common gynecological disorder caused by chronic pelvic venous congestion. Clinically, it primarily manifests as lower abdominal pain, lower back pain, dyspareunia, increased menstrual flow, and increased vaginal discharge, though positive physical signs are few. The gynecological examination may reveal bilateral ovarian tenderness.

Association between maternal androgen levels and early fetal sex differentiation: Anogenital distance and genital tubercle length in the first trimester.

Purpose: To evaluate the use of anogenital distance (AGD) and genital tubercle length (GTL) between 11 and 13 + 6 weeks of gestation for fetal sex determination and to assess the impact of maternal androgen levels on these measurements.

Methods: A cross-sectional study was conducted from February to June 2017 with patients undergoing first trimester Down syndrome screening. Inclusion criteria were: (1) female age 18-49, (2) gestational age between 11 and 13 + 6 weeks, (3) optimal visualization of AGD and GTL, and (4) nonsmoking status.

Women's care satisfaction and birth experiences in a Danish urban university hospital: A comparative cross-sectional study on midwifery-led continuity of care and standard midwifery care models.

Problem: Despite solid evidence and national recommendations supporting midwife-led continuity-of-care models, Danish women's access to such programs remains limited.

Background: A public birth facility introduced a midwife-led continuity-of-care model, targeting a subset of women receiving antenatal and intrapartum care.

Aim: To compare care satisfaction during pregnancy and birth and birth experience between women receiving midwife-led continuity of care and those receiving standard midwifery care.

Additional value of fetal magnetic resonance imaging for prenatal diagnosis: A retrospective study.

Objective: This study aimed to evaluate the utility of fetal MRI in prenatal diagnosis.

Methods: A retrospective study was conducted, including all pregnant women who underwent fetal MRI at a single French university center from 2018 to 2022. Fetal MRI findings were deemed "concordant" if they matched the ultrasound diagnosis.

Human embryo implantation: The complex interplay between endometrial receptivity and the microbiome.

The endometrial and vaginal microbiota have co-evolved with the reproductive tract and play a key role in both health and disease. However, the difference between endometrial and vaginal microbiota, as well as their association with reproductive outcomes in women undergoing frozen embryo transfer, remains unclear. 120 women who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and whole embryo freezing were enrolled.