4 results match your criteria: "Department of Neurology and Neurosurgery University of Tartu Tartu Estonia.[Affiliation]"
Background Women have worse outcomes after stroke than men, and this may be partly explained by stroke severity. We examined factors contributing to sex differences in severity of acute stroke assessed by the National Institutes of Health Stroke Scale. Methods and Results We pooled individual participant data with National Institutes of Health Stroke Scale assessment (N=6343) from 8 population-based stroke incidence studies (1996-2014), forming part of INSTRUCT (International Stroke Outcomes Study).
View Article and Find Full Text PDFObjectives: Levodopa is the most effective therapy for treating Parkinson's disease (PD); however, side effects such as dyskinesias and motor fluctuations may occur after some years of its usage. The aims of this study were to assess the frequency of and factors associated with motor complications among PD patients on levodopa treatment.
Methods: In a cross-sectional study carried out in 2010-2013, clinical data and treatment details were collected.
Article Synopsis
- - The MDS-UPDRS is a new tool designed to evaluate Parkinson's disease and this study aimed to analyze its score changes based on disease duration and Hoehn and Yahr (HY) stages in a large group of patients.
- - The research involved 3,206 patients, revealing that scores for the MDS-UPDRS Parts I through IV increased significantly across HY stages and in 5-year increments for the first 15 years of the disease.
- - Specifically, the study found average point increases for MDS-UPDRS components according to HY stage and disease duration, indicating a progressive worsening of symptoms in early to mid-stages of Parkinson's disease.
Background: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1-weighted MRI.
Methods: We have investigated brain structure and function in methcathinone abusers ( = 12) compared to matched control subjects ( = 12) using T1-weighted structural and resting-state functional MRI.