Effects of early rehabilitation nursing on neurological functions and quality of life of patients with ischemic stroke hemiplegia.

Objective: This study aimed at exploring the effects of early rehabilitation nursing (ERN) on the neurological functions, the incidence of lower extremity deep venous thrombosis (LEDVT) and the quality of life (QOL) of patients with ischemic stroke hemiplegia (ISH).

Methods: Admitted to our hospital from January 2018 to February 2019, 123 patients with ISH were enrolled, among which 70 cases received routine nursing (a control group) and 53 cases received ERN (a study group). The patients in the two groups were compared with respect to the scores of the European Stroke Scale (ESS), the Barthel Index (BI) and the Fugl-Meyer Assessment (FMA), the incidences of complications and LEDVT, QOL and nursing satisfaction.

Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression.

Discriminating depressive episodes of bipolar disorder (BD) from major depressive disorder (MDD) is a major clinical challenge. Recently, gut microbiome alterations are implicated in these two mood disorders; however, little is known about the shared and distinct microbial characteristics in MDD versus BD. Here, using 16S ribosomal RNA (rRNA) gene sequencing, the microbial compositions of 165 subjects with MDD are compared with 217 BD, and 217 healthy controls (HCs).

[Gastrodin improves hippocampal neurogenesis by NO-cGMP-PKG signaling pathway in cerebral ischemic mice].

This paper was aimed to investigate the effect of gastrodin( GAS) on hippocampal neurogenesis after cerebral was chemic and to explore its mechanism of action related to NO. The cerebral ischemia model of C57 BL/6 mice was established by bilateral common carotid artery occlusion. The pathological changes in hippocampal CA1 region and the cognitive function of mice were assessed by HE staining and Morris water maze test,respectively.

Perturbed Microbial Ecology in Myasthenia Gravis: Evidence from the Gut Microbiome and Fecal Metabolome.

Myasthenia gravis (MG) is a devastating acquired autoimmune disease. Emerging evidence indicates that the gut microbiome plays a key role in maintaining immune system homeostasis. This work reports that MG is characterized by decreased α-phylogenetic diversity, and significantly disturbed gut microbiome and fecal metabolome.