6 results match your criteria: "Department of Neurology Seoul National University Hospital Seoul South Korea.[Affiliation]"
Article Synopsis
- Perioperative stroke is a serious risk following surgery, usually identified through prediction models that focus mainly on preoperative patient characteristics.
- This study utilized data from over 15,000 patients to develop a new machine-learning model that includes both preoperative and intraoperative variables for better stroke risk assessment.
- The integrated model showed significantly better performance in predicting perioperative stroke compared to models relying only on preoperative factors, indicating the importance of real-time intraoperative data.
Background Unlike patients with stroke caused by other mechanisms, the effect of elevated plasma total homocysteine (tHcy) on the prognosis of patients with both ischemic stroke and atrial fibrillation (AF) is unknown. This study aimed to evaluate the association between tHcy level and the functional outcome of patients with AF-related stroke. Methods and Results We included consecutive patients with AF-related stroke between 2013 and 2015 from the registry of a real-world prospective cohort from 11 large centers in South Korea.
View Article and Find Full Text PDFInterest in autoimmune encephalitis has been growing since the discovery of various autoimmune antibodies, such as -methyl D-aspartate receptors antibody and leucine-rich glioma-inactivated 1 antibody. However, in contrast to autoimmune encephalitis associated with dysregulated adaptive immunity in the brain, the question of whether innate immunity-mediated autoinflammatory diseases exist in the brain has drawn much attention. Herein, we report a patient with microglia-dominant acute autoinflammatory encephalitis successfully treated with anakinra, an including interleukin-1 receptor blocker.
View Article and Find Full Text PDFObjective: To evaluate the therapeutic potential of bortezomib, a proteasome inhibitor that target plasma cells, in order to revive stalled recovery in patients with anti--methyl-d-aspartate (NMDA) receptor encephalitis who remain bedridden even after aggressive immunotherapy.
Methods: We consecutively enrolled patients with anti-NMDA receptor encephalitis who remained bedridden after first-line immunotherapy (steroids and intravenous immunoglobulin), second-line immunotherapy (rituximab), and tocilizumab treatment, and treated them with subcutaneous bortezomib. Clinical response, functional recovery, and changes in antibody titer in the serum and cerebrospinal fluid were measured.
Objective: We aimed to evaluate the impact of underlying mechanism of basilar artery (BA) occlusion on the outcomes after endovascular therapy (EVT) for reperfusion and the outcome factors associated with each mechanism, and to identify radiologic parameters enabling to distinguish the underlying mechanism.
Methods: From a registry database, 194 consecutive patients with acute BA occlusion who underwent EVT were analyzed. Stroke mechanism, classified into in situ atherosclerotic thrombosis (ISAT) and embolism, clot sign location profiles in pre-angiography magnetic resonance image (MRI), parameters of angiography and EVT, and reperfusion were assessed.
Hypersalivation is one of the intractable symptoms of anti--methyl-d-aspartate receptor (NMDAR) encephalitis. While anticholinergic medications partially improve the hypersalivation, they can aggravate the autonomic dysfunctions associated with anti-NMDAR encephalitis. Thus, we investigated the efficacy and safety of botulinum toxin type A injection on hypersalivation refractory to anticholinergics in six patients with anti-NMDAR encephalitis.
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