8 results match your criteria: "Department of Neurology Juntendo University School of Medicine Tokyo Japan.[Affiliation]"
Background: Early-onset Parkinson's disease (EOPD)/young-onset Parkinson's disease (YOPD) is defined as Parkinson's disease (PD) with an age at onset (AAO) after age 21 years but before the usual AAO for PD. Consensus is lacking, and the reported maximal age for EOPD/YOPD has varied from 40 to 60 years, leading to a lack of uniformity in published studies and difficulty in harmonization of data. EOPD and YOPD have both been used in the literature, somewhat interchangeably.
View Article and Find Full Text PDFBackground: Nonmotor symptoms (NMSs) of Parkinson's disease (PD) impair health-related quality of life.
Objectives: To identify changes in NMSs during 52 weeks in Japanese PD patients exhibiting motor fluctuations.
Methods: In PD patients with ≥1 NMS and wearing-off, changes in total/subscore of the Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part I and 8-item PD Questionnaire were assessed.
Article Synopsis
- The study focuses on how mutations in the PARK2 gene, linked to autosomal recessive familial Parkinson's disease, may disrupt metabolic pathways, leading to altered serum metabolomics profiles in affected individuals.
- Researchers analyzed serum samples from 15 PARK2 patients and 19 healthy controls, identifying significant differences in metabolite levels, particularly higher fatty acid metabolites and oxidized lipids, alongside lower levels of antioxidants and caffeine-related compounds.
- The findings suggest a relationship between parkin dysfunction, lipid metabolism, and oxidative stress, indicating that serum metabolomics could be a valuable tool for understanding the metabolic changes associated with Parkinson's disease.