7 results match your criteria: "Department of Neurology Hannover Medical School[Affiliation]"
Background A substantial proportion of ischemic strokes remain cryptogenic, which has important implications for secondary prevention. Identifying genetic variants related to mechanisms of stroke causes may provide a chance to clarify the actual causes of cryptogenic strokes. Methods and Results In a 2-step process, 2 investigators independently and systematically screened studies that reported genetic variants in regard to stroke causes that were published between January 1991 and April 2021.
View Article and Find Full Text PDFCommon Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
Mov Disord
October 2022
Department of Neurology Hannover Medical School, Hannover, Germany.
Article Synopsis
- Multiple System Atrophy (MSA) is a rare neurodegenerative disease characterized by abnormal protein aggregation and leads to motor and autonomic dysfunction.
- Previous genetic studies didn’t find variants linked to MSA, prompting researchers to focus on autopsy-confirmed cases rather than merely clinical diagnoses.
- The study identified significant genetic markers associated with MSA (located on chromosomes 3, 4, and 8), particularly highlighting the potential role of the ZIC4 gene in neuron vulnerability, especially in patients with different MSA types.
Background: Rechargeable implantable pulse generator (IPG) technology has several advantages over non-rechargeable systems and is routinely used now in deep brain stimulation (DBS). Little is known about the occasional need and the circumstances for switching back to non-rechargeable technology.
Cases: Out of a cohort of 640 patients, 102 patients received a rechargeable IPG at first implantation or at the time of replacement surgery.
We describe the case of a 59-year-old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F-FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia or progressive supranuclear palsy, genetic testing eventually revealed Huntington's disease.
View Article and Find Full Text PDFSince the incidental discovery in 1981 that intravenous immunoglobulins (IVIg) are immunomodulatory, they have been investigated in a large number of putative autoimmune diseases. This has led to licensing for idiopathic thrombocytopenic purpura, Kawasaki disease, and in neurological disorders for Guillain-Barré syndrome (GBS). Although not licensed, randomized controlled trials have also shown IVIg efficacy in other neuroimmunological diseases such as multifocal motor neuropathy (MMN), chronic inflammatory demyelinating neuropathy (CIDP), myasthenia gravis, dermatomyositis, and stiff-person syndrome.
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