2 results match your criteria: "Department of Neurology Cangzhou Central Hospital[Affiliation]"
Article Synopsis
- Statins are commonly used to prevent further strokes in patients with mild ischemic stroke, but it is unclear if higher doses are beneficial in Asian populations.
- A study comparing high-dose and moderate-dose statins found no significant difference in stroke recurrence rates at 3 and 12 months, suggesting both doses are similarly effective.
- However, high-dose statins were linked to a higher risk of intracranial hemorrhage, indicating potential safety concerns with more intensive treatment.
CERKL alleviates ischemia reperfusion-induced nervous system injury through modulating the SIRT1/PINK1/Parkin pathway and mitophagy induction.
Biol Chem
June 2022
Department of Neurology Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou 061000, Hebei, China.
Recent studies showed that Ceramide Kinase-Like Protein (CERKL)was expressed in the nerve cells and could regulate autophagy. Sirtuin-1 (SIRT1) is the regulator of the mitophagy, which can be stabilized by CERKL. Furthermore, the study also revealed that the SIRT1 induced mitophagy by activating PINK1/Parkin signaling.
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