5 results match your criteria: "Department of Neurology Boston Children's Hospital Harvard Medical School Boston Massachusetts.[Affiliation]"
We evaluated the integration of the Rapid Interactive screening Test for Autism in Toddlers (RITA-T) model in a community, comparing autism spectrum disorder (ASD) toddlers' demographic and socioeconomic characteristics. Of 394 ASD toddlers, 323 were screened with RITA-T. Those screened were from more deprived areas, traveled farther and were diagnosed earlier.
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- The TAND Checklist is a valuable tool to screen for neuropsychiatric disorders associated with tuberous sclerosis complex (TSC).
- It consists of six dimensions and 12 sections, making it a detailed assessment framework.
- When used with Chinese individuals who have TSC, the checklist helps evaluate a wide range of potential symptoms effectively.
Pain affect disrupted in children with posterior cerebellar tumor resection.
Ann Clin Transl Neurol
February 2019
Center for Pain and the Brain Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts 02215.
Objectives: Damage to the posterior cerebellum can cause affective deficits in patients. In adults, cerebellar infarcts result in thermal hyperalgesia and affect descending modulation of pain. This study evaluated the effect of resection of low-grade cerebellar tumors on pain processing in human children.
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- SSADH deficiency leads to increased levels of GABA and GHB, causing serious neurological issues like epilepsy and behavioral disturbances, with a high risk of Sudden Unexplained Death in Epilepsy (SUDEP).
- The study involved 133 subjects, noting a 50% epilepsy prevalence, particularly in those over 12, with absence seizures showing earlier onset than generalized tonic-clonic seizures in the younger population.
- Findings suggest the degree of epilepsy and other behavioral issues worsens with age, influenced by fluctuations in GABA, GHB levels, and thyroid function, potentially paralleling seizure progression observed in animal studies.
Objective: To evaluate if short-term treatment with everolimus was safe and could improve neurocognition and behavior in children with TSC.
Methods: This was a prospective, double-blind randomized, placebo-controlled two-center phase II study. Participants diagnosed with TSC and age 6-21 years were treated with 4.