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Article Synopsis
  • Lupus nephritis, a serious complication of systemic lupus erythematosus, can lead to nephrotic syndrome or chronic kidney disease, potentially resulting in end-stage renal failure.
  • Research highlights that the accumulation of interstitial macrophages and associated fibrosis is more crucial for kidney health than glomerular immunoglobulin deposits or macrophage presence.
  • Targeting specific macrophage-related proteins and blocking their signaling pathways may offer promising treatments for ameliorating kidney damage while preserving overall kidney function.
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