Lupus nephritis, a serious complication of systemic lupus erythematosus, can lead to nephrotic syndrome or chronic kidney disease, potentially resulting in end-stage renal failure.
Research highlights that the accumulation of interstitial macrophages and associated fibrosis is more crucial for kidney health than glomerular immunoglobulin deposits or macrophage presence.
Targeting specific macrophage-related proteins and blocking their signaling pathways may offer promising treatments for ameliorating kidney damage while preserving overall kidney function.