1 results match your criteria: "Department of Molecular Genetics and Microbiology University of Florida College of Medicine[Affiliation]"
The C-terminal 88 amino acids of the Sendai virus P protein have multiple functions separable by mutation.
J Virol
January 2002
Department of Molecular Genetics and Microbiology University of Florida College of Medicine, Gainesville, Florida 32610, USA.
Article Synopsis
- The Sendai virus P-L polymerase complex connects with the NP-encapsidated nucleocapsid (NC) via a specific interaction between the proteins P and NP.
- Researchers used site-directed mutagenesis on the last 88 amino acids of the NC binding domain in the P protein to pinpoint which amino acids are crucial for binding.
- While some mutant P proteins maintained normal function, others showed defects in transcription and genome replication, highlighting the multi-functional role of the P protein in the viral replication process beyond just binding to NC.