2 results match your criteria: "Department of Molecular Biology and the Joint Center of Structural Genomics[Affiliation]"
Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR.
J Struct Funct Genomics
December 2005
The Scripps Research Institute, Department of Molecular Biology and the Joint Center of Structural Genomics, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
In structural genomics centers, nuclear magnetic resonance (NMR) screening is in increasing use as a tool to identify folded proteins that are promising targets for three-dimensional structure determination by X-ray crystallography or NMR spectroscopy. The use of 1D 1H NMR spectra or 2D [1H,15N]-correlation spectroscopy (COSY) typically requires milligram quantities of unlabeled or isotope-labeled protein, respectively. Here, we outline ways towards miniaturization of a structural genomics pipeline with NMR screening for folded globular proteins, using a high-density micro-fermentation device and a microcoil NMR probe.
View Article and Find Full Text PDFNMR structure of the conserved hypothetical protein TM0979 from Thermotoga maritima.
Proteins
May 2005
Department of Molecular Biology and the Joint Center of Structural Genomics, The Scripps Research Institute, La Jolla, California 92037, USA.