4 results match your criteria: "Department of Microbiology and Immunology- Faculty of Pharmacy- Zagazig University- Zagazig[Affiliation]"
Could the analgesic drugs, paracetamol and indomethacin, function as quorum sensing inhibitors?
Microb Pathog
September 2021
Department of Microbiology and Immunology- Faculty of Pharmacy- Zagazig University- Zagazig, 44519, Egypt. Electronic address:
The current failure of antimicrobials in treating life-threatening diseases, the high rate of multidrug resistant pathogens and the slow progress in the development of new antibiotics directed scientists to develop antivirulence drugs that targets quorum sensing (QS). In many microbes, QS acts as a communication system which control pathogenicity of microbes. Analgesics can be beneficial in controlling virulence traits of microbes and hence they may augment the efficacy of antimicrobials.
View Article and Find Full Text PDFGlyceryl trinitrate blocks staphyloxanthin and biofilm formation in .
Afr Health Sci
March 2019
Department of Medicinal Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Background: is an important nosocomial bacterium that is responsible for a number of infections that may be fatal. The treatment of such infections is limited by emergence of antibiotic resistance. Targeting virulence of may provide an alternative option to antibiotic that may bypass the emergence of resistant strains due to lack of stress on viability.
View Article and Find Full Text PDFRelationship between Sap prevalence and biofilm formation among resistant clinical isolates of .
Afr Health Sci
December 2018
Department of Microbiology and Biotechnology-Faculty of Pharmacy- Delta University for Science and Technology- International coastal road, Gamasa city, Mansoura, Dakhaliya Egypt.
Article Synopsis
- Fungal infections pose significant health risks, especially for those with weakened immune systems, with a focus on a common fungus known for high mortality rates.
- The study investigates the link between the fungus's ability to form biofilms, its proteolytic activity, and specific genetic markers associated with reduced susceptibility to antifungal agents.
- Results showed that some strains exhibited resistance to multiple antifungal drugs, were strong biofilm producers, and contained relevant genes, highlighting the connection between antifungal resistance and virulence factors in these isolates.
Repurposing metformin as a quorum sensing inhibitor in .
Afr Health Sci
September 2017
Department of Medicinal Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Background: Quorum sensing is a mechanism of intercellular communication that controls the production of virulence factors in . Inhibition of quorum sensing can disarm the virulence factors without exerting stress on bacterial growth that leads to emergence of antibiotic resistance.
Objectives: Finding a new quorum sensing inhibitor and determining its inhibitory activities against virulence factors of PAO1 strain.