9 results match your criteria: "Department of Medicine and Surgery University of Parma Parma Italy.[Affiliation]"

A portion of multiple myeloma (MM) patients relapse early or do not respond to first line treatment. Identification of possible clinical and or biological features of these patients remains an unmet medical need. In this study we assesed the predictive markers for early relapse MM, defined as a progressive disease that occurred within 18 months, from autologoust stem cell transplantation (ASCT) in MM patients who did not have primary refractory disease.

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Article Synopsis
  • T-lineage acute lymphoblastic leukemia (T-ALL) is a serious type of cancer that affects a significant percentage of children and adults, with poor outcomes for those who relapse or resist treatment.
  • Understanding the role of the proto-oncogene MYB is crucial as it is linked to increased T-ALL aggression and worse patient survival, particularly in pediatric cases.
  • This study reveals that high MYB levels drive T-ALL development and that targeting MYB's function could offer a promising new treatment approach.
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Alpha-1 antitrypsin deficiency is an autosomal, codominant disorder caused by mutations of the gene. Several mutations of have been described associated with the development of pulmonary emphysema and/or chronic liver disease and cirrhosis. Here, we report a very rare variant identified for the first time in an Italian family originally from the city of Parma in Northern Italy.

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Introduction: Frontotemporal dementia (FTD) is a neurodegenerative disorder for which there is no effective pharmacological treatment. Recently, interneuron activity responsible for fast oscillatory brain activity has been found to be impaired in a mouse model of FTD with consequent cognitive and behavioral alterations. In this study, we aim to investigate the safety, tolerability, and efficacy of a novel promising therapeutic intervention for FTD based on 40 Hz transcranial alternating current stimulation (tACS), a form of non-invasive brain stimulation thought to engage neural activity in a frequency-specific manner and thus suited to restore altered brain oscillatory patterns.

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The treatment of Bouveret syndrome lacks specific guidelines and is strictly interdisciplinary. Especially, if electrohydraulic lithotripsy is not available and endoscopic removal fails, a timely surgical approach is advised.

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Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements.

Design: Instrument development and cross-sectional study for psychometric testing.

Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018-January 2019.

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Tonsillar lymphoma usually presents as unilateral or bilateral infiltration of diffuse large B-cell lymphomas. We report a case of a 79-year-old man with near-complete obstruction of the upper airways due to T-cell prolymphocytic leukemia cells. Surgical resection was safely performed to reduce burden of disease.

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Actinomycosis is a rare, chronic granulomatous infection, frequently associated with immunocompromised states, but it can also affect healthy people. Here, we report a case of a pulmonary infection by and due to a dental caries in an immunocompetent 65-year-old man patient.

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Pleural effusions may be related to pleuro-pulmonary or systemic disorders, including malignancy. Thoracentesis and thoracoscopy may be useful to diagnosis. In some cases, the diagnosis may be difficult and uncommon.

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