15 results match your criteria: "Department of Medicine and Department of Clinical Epidemiology[Affiliation]"
Financial Costs Incurred by Living Kidney Donors: A Prospective Cohort Study.
J Am Soc Nephrol
December 2018
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Background: Approximately 40% of the kidneys for transplant worldwide come from living donors. Despite advantages of living donor transplants, rates have stagnated in recent years. One possible barrier may be costs related to the transplant process that potential willing donors may incur for travel, parking, accommodation, and lost productivity.
View Article and Find Full Text PDFClinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient: 2016 update-executive summary.
Am J Health Syst Pharm
January 2017
Department of Medicine, Mount Sinai Hospital, Toronto, Canada.
Airway Management Strategies for Brain-injured Patients Meeting Standard Criteria to Consider Extubation. A Prospective Cohort Study.
Ann Am Thorac Soc
January 2017
1 Interdepartmental Division of Critical Care and.
Rationale: Patients with acute brain injury are frequently capable of breathing spontaneously with minimal ventilatory support despite persistent neurological impairment.
Objectives: We sought to describe factors associated with extubation timing, success, and primary tracheostomy in these patients.
Methods: We conducted a prospective multicenter observational cohort study in three academic hospitals in Toronto, Canada.
CanVasc recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides - Executive summary.
Can J Kidney Health Dis
November 2015
Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario Canada.
Article Synopsis
- The Canadian Vasculitis research network (CanVasc) consists of a diverse group of physicians and researchers focused on vasculitis.
- One of their main goals is to create guidelines for diagnosing and managing ANCA-associated vasculitides in Canada.
- This summary includes 19 recommendations and 17 statements that cover general diagnosis and management of AAV, based on international guidelines and expert consensus tailored to the Canadian healthcare environment.
CanVasc Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitides.
J Rheumatol
January 2016
From the Department of Rheumatology, Mount Sinai Hospital, University of Toronto; Division of Nephrology, University Health Network, Toronto; Division of Rheumatology, Division of Respirology, and Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, St. Joseph's Healthcare, Hamilton; Division of Rheumatology, St. Joseph's Health Care, London; Langs Community Centre, Cambridge; Division of Rheumatology, the Ottawa Hospital/University of Ottawa, Ottawa; Division of Rheumatology and the Arthritis Program Research Group in Newmarket, Newmarket; Department of Medicine, Queen's University, Kingston, Ontario; Division of Pediatric Rheumatology, Alberta Children's Hospital, and Division of Rheumatology, University of Calgary, Calgary; Division of Rheumatology, University of Alberta, Edmonton, Alberta; Division of Rheumatology, QEII Health Sciences Centre and Dalhousie University; Division of Nephrology, Dalhousie University, Halifax, Nova Scotia; Division of Pediatric Rheumatology, BC Children's Hospital and University of British Columbia; Division of Rheumatology, Arthritis Research Canada, University of British Columbia, Vancouver, British Columbia; Section of Rheumatology, University of Manitoba, Arthritis Centre, Winnipeg, Manitoba; Division of Internal Medicine, Hôpital Du Sacré-Coeur; Division of Rheumatology, Lupus and Vasculitis clinic, McGill University, Montréal; Division of Rheumatology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke; Division of Rheumatology, CHAU Hôtel-Dieu de Lévis, Université Laval, Quebec City, Québec; Division of Rheumatology, Memorial University of Newfoundland, Nexus Clinical Research, St. John's, Newfoundland; Division of Rheumatology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.L. McGeoch, MD, Department of Rheumatology, Mount Sinai Hospital, University of Toronto, currently: Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK; M. Twilt,
Objective: The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties and researchers with expertise in vasculitis. One of its aims is to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada.
Methods: Diagnostic and therapeutic questions were developed based on the results of a national needs assessment survey.
The Safety of Eplerenone in Hemodialysis Patients: A Noninferiority Randomized Controlled Trial.
Clin J Am Soc Nephrol
September 2015
Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
Background And Objectives: Mineralocorticoid receptor antagonism reduces morbidity and mortality in patients with heart failure, but the safety of these drugs in patients receiving dialysis is unclear. This study evaluated whether hyperkalemia and/or hypotension limited the use of eplerenone, a selective mineralocorticoid receptor antagonist, in hemodialysis patients.
Design, Setting, Participants, & Measurements: This was a randomized controlled trial of prevalent patients receiving hemodialysis at five Canadian centers.
The Relationship Between Dermatologist- and Patient-Reported Acne Severity Measures and Treatment Recommendations.
J Cutan Med Surg
November 2015
Institute of Cosmetic and Laser Surgery, Oakville, ON, Canada.
Background: Acne treatment recommendations for individual patients may be derived from multiple factors including dermatologist- and patient-reported constructs.
Objectives: To evaluate the effects of dermatologist- and patient-reported measures on acne treatment recommendations by dermatologists.
Methods: An observational cross-sectional survey of acne patients was conducted with patient-reported quality of life and dermatologist-reported measures of primary and secondary (scar) acne severity using 3 assessment approaches: maximal regional grade, total grade, and facial grade.
Admission of the very elderly to the intensive care unit: family members' perspectives on clinical decision-making from a multicenter cohort study.
Palliat Med
April 2015
Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada.
Background: Little is known about the perspectives and experiences of family members of very elderly patients who are admitted to the intensive care unit.
Aim: To describe family members' perspectives about care provided to very elderly critically ill patients.
Design: Multicenter, prospective, cohort study.
The authors reply.
Crit Care Med
May 2014
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany, and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany, and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored.
Lancet Diabetes Endocrinol
October 2014
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
In patients with type 1 or type 2 diabetes, glycaemic exposure assessed as HbA1c correlates strongly with risk of future microvascular and macrovascular complications. Improved glucose control substantially reduces the risk of microvascular complications and, with extended follow-up, modestly reduces the risk of atherosclerotic events. The lowering of HbA1c concentrations by newly developed glucose-lowering drugs (alone or when added to other glucose-lowering drugs) has been used, until recently, as a surrogate measure of their potential to lower cardiovascular risk.
View Article and Find Full Text PDFTreatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach.
J Rheumatol
April 2014
From the Dartmouth-Hitchcock Medical Center, Rheumatology; Geisel School of Medicine at Dartmouth, The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire; Veterans Affairs, VA National Center for Patient Safety, White River Junction, New Hampshire; Northeastern Ohio Universities College of Medicine, Rootstown, Ohio; Boston University School of Medicine, Department of Medicine and Department of Clinical Epidemiology, Boston, Massachusetts, USA.
Objective: Elevated serum urate may be associated with an increase in cardiovascular (CV) disease. Treating asymptomatic hyperuricemia with urate-lowering drugs such as allopurinol may reduce CV events. We designed a model to simulate the effect of allopurinol treatment on reducing frequency of CV events in individuals with elevated serum urate.
View Article and Find Full Text PDFThe authors reply.
Crit Care Med
December 2013
Department of Intensive Care Medicine, Versailles University and Raymond Poincaré Hospital, Garches, France; Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University and St. Joseph's Hospital, Hamilton, Canada; Department of Medicine, Cooper Medical School of Rowan University and Chief, Medicine Service at Cooper University Hospital, Camden, NJ.
The authors reply.
Crit Care Med
October 2013
Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster, University and St. Joseph's Hospital, Hamilton, ON, Canada Intensive Care Unit, Royal Perth Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia Department of Intensive Care Medicine, Raymond Poincaré, Hospital (AP-HP), School of Medicine Simone Veil, University of Versailles SQY, Garches, France Department of Medicine, Cooper Medical School of Rowan University and Cooper University Hospital, Camden, NJ.
Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest
February 2012
Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address:
Background: This guideline focuses on long-term administration of antithrombotic drugs designed for primary and secondary prevention of cardiovascular disease, including two new antiplatelet therapies.
Methods: The methods of this guideline follow those described in Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines in this supplement.
Results: We present 23 recommendations for pertinent clinical questions.
Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.
Crit Care
February 2005
Department of Medicine and Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.