Effect of Osteoblast-Specific Deletion of the Proton Receptor OGR1.

Metabolic acidosis (MET) stimulates bone resorption through inhibition of osteoblast (OB) bone formation and stimulation of osteoclast (OC) bone resorption. We found that OGR1, a G protein-coupled proton (H)-sensing receptor, was critical for initial H signaling in the OB. In mice with a global deletion of OGR1, we demonstrated that loss of OGR1 impairs H-induced bone resorption, leading to increased bone density through effects on both the OB and OC.

RSV-associated hospitalization in adults in the USA: A retrospective chart review investigating burden, management strategies, and outcomes.

Background And Aims: The burden of respiratory syncytial virus (RSV) infection in adults is of growing concern. This study was designed to quantify disease burden, treatment approaches, and outcomes associated with RSV infections in adult subpopulations, from prehospitalization to hospital discharge.

Methods: A retrospective chart analysis was conducted to collect patient-case data from hospitalized US adults (aged >18 years) with RSV infection during two RSV seasons.

Chlorthalidone with potassium citrate decreases calcium oxalate stones and increases bone quality in genetic hypercalciuric stone-forming rats.

To study human idiopathic hypercalciuria we developed an animal model, genetic hypercalciuric stone-forming rats, whose pathophysiology parallels that of human idiopathic hypercalciuria. Fed the oxalate precursor, hydroxyproline, every rat in this model develops calcium oxalate stones. Using this rat model, we tested whether chlorthalidone and potassium citrate combined would reduce calcium oxalate stone formation and improve bone quality more than either agent alone.

Triple atrial sensing during cardiac resynchronization.

This report describes a patient who underwent cardiac resynchronization complicated by a Twiddler syndrome. This caused triple atrial sensing and an inappropriate shock.