6 results match your criteria: "Department of Medicine University of California San Diego La Jolla CA USA.[Affiliation]"
Article Synopsis
- This study explores a new method for accurately calculating fractional flow reserve (FFR) using coronary angiography to better identify patients who need intervention.
- The research involved a comparison of this new FFR framework against traditional wire-based FFR in 160 patients, revealing strong diagnostic performance metrics, such as a sensitivity of 79.3% and specificity of 95.4%.
- A key finding was the identification of longitudinal vorticity as a significant hemodynamic marker indicating the risk of major adverse cardiac events in patients who haven't undergone revascularization.
Background The relationship between alcohol consumption and ectopic fat distribution, both known factors for cardiovascular disease, remains understudied. Therefore, we aimed to examine the association between alcohol consumption and ectopic adiposity in adults at risk for cardiovascular disease. Methods and Results In this cross-sectional analysis, we categorized alcohol intake among participants in MESA (Multi-Ethnic Study of Atherosclerosis) as follows (drinks/day): <1 (light drinking), 1 to 2 (moderate drinking), >2 (heavy drinking), former drinking, and lifetime abstention.
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- Lower respiratory tract infections primarily affect children and lead to many hospital admissions, with COVID-19 stay-at-home orders significantly reducing these admissions.
- Researchers in San Diego County utilized this period to analyze pediatric emergency department visits for respiratory issues, examining 72,333 cases and fine-scale changes in air quality.
- The study revealed a 4% reduction in pediatric respiratory visits was linked to improved air quality during the stay-at-home order, highlighting spatial disparities in health outcomes across different ZIP codes.
Life with FASEB for three decades.
FASEB Bioadv
October 2021
Department of Bioengineering, Department of Medicine, and Institute of Engineering in Medicine University of California San Diego La Jolla CA USA.
As APS President-elect, I participated in the Williamsburg Retreat in 1989 to address the issue of keeping member societies in FASEB. The Retreat led to focusing on public affairs and reducing society dues. As APS President, I met with leadership of ASBMB to convince them to remain in the restructured FASEB.
View Article and Find Full Text PDFThe transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1-KRIT1 protein complex that establishes and maintains junctional integrity. Genetic inactivation or knockdown of endothelial HEG1 or KRIT1 leads to the upregulation of transcription factors Krüppel-like factors 4 and 2 (KLF4 and KLF2), which are implicated in endothelial vascular homeostasis; however, the effect of acute inhibition of the HEG1-KRIT1 interaction remains incompletely understood. Here, we report a high-throughput screening assay and molecular design of a small-molecule HEG1-KRIT1 inhibitor to uncover acute changes in signaling pathways downstream of the HEG1-KRIT1 protein complex disruption.
View Article and Find Full Text PDFDisease extent and anti-tubercular treatment response correlates with -specific CD4 T-cell phenotype regardless of HIV-1 status.
Clin Transl Immunology
September 2020
Objectives: The development of non-sputum-based assays for tuberculosis (TB) diagnosis and treatment monitoring is a key priority. Recent data indicate that whole blood-based assays to assess the phenotype of (Mtb)-specific CD4 T cells hold promise for this purpose and require further investigation in well-characterised TB cohorts. In this study, we investigated the relationship between the phenotypic signature of Mtb-specific CD4 responses, TB disease extent and treatment response.
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