7 results match your criteria: "Department of Medicine UT Southwestern Medical Center Dallas TX.[Affiliation]"
Racial and Socioeconomic Health Disparities in Peripheral Artery Disease.
J Am Heart Assoc
November 2024
Division of Cardiovascular Medicine, Department of Internal Medicine Vanderbilt University Medical Center Nashville TN USA.
Article Synopsis
- Peripheral artery disease (PAD) is a worsening condition causing narrowing of the arteries in the legs, leading to serious risks like heart attacks and amputations, particularly affecting marginalized racial and ethnic groups in the U.S.
- Despite advances in treatment, outcomes for PAD remain worse for Black, Hispanic, and American Indian populations compared to White individuals, highlighting significant health disparities.
- Research increasingly emphasizes the importance of social determinants of health, rather than biological factors, in understanding these disparities and suggests that improved policies and strategies could promote health equity.
Article Synopsis
- Elevated plasma levels of alpha-aminoadipic acid (2-AAA) are linked to type 2 diabetes and atherosclerosis, but the exact relationship is unclear.
- A genetic analysis of over 5,400 individuals found no definitive genetic variants related to 2-AAA across all samples, though associations were noted with genes involved in mitochondrial function and macrophage activity.
- The study used Mendelian randomization to suggest that higher levels of 2-AAA may be inversely associated with lower high-density lipoprotein (HDL) cholesterol, indicating a potential link between 2-AAA levels and cardiometabolic risk, warranting further research.
Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report.
J Am Heart Assoc
August 2021
Division of Research Kaiser Permanente Northern California Oakland CA.
There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced-based secondary prevention strategies.
View Article and Find Full Text PDFBackground Physical inactivity and low cardiorespiratory fitness (CRF) are associated with higher risk of heart failure. However, the independent contributions of objectively measured sedentary time, physical activity, and CRF toward left ventricular (LV) structure and function are not well established. Methods and Results We included 1368 participants from the DHS (Dallas Heart Study) (age, 49 years; 40% men) free of cardiovascular disease who had physical activity and sedentary time measured by accelerometer, CRF estimated from submaximal treadmill test, and cardiac magnetic resonance imaging performed using 3-T magnetic resonance imaging.
View Article and Find Full Text PDFBackground We systematically reviewed trials comparing different reperfusion strategies for ST-segment-elevation myocardial infarction and used multivariate network meta-analysis to compare outcomes across these strategies. Methods and Results We identified 31 contemporary trials in which patients with ST-segment-elevation myocardial infarction were randomized to ≥2 of the following strategies: fibrinolytic therapy (n=4212), primary percutaneous coronary intervention (PCI) (n=6139), or fibrinolysis followed by routine early PCI (n=5006). We categorized the last approach as "facilitated PCI" when the median time interval between fibrinolysis to PCI was <2 hours (n=2259) and as a "pharmacoinvasive approach" when this interval was ≥2 hours (n=2747).
View Article and Find Full Text PDFBackground The incidence and clinical manifestations of cardiovascular disease (CVD) differ between blacks and whites. Biomarkers that reflect important pathophysiological pathways may provide a window to allow deeper understanding of racial differences in CVD. Methods and Results The study included 2635 white and black participants from the Dallas Heart Study who were free from existing CVD.
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