Evaluation of colour vision impairment during acute hypobaric hypoxia in aviation medicine: a randomized controlled trial.

The digitization of aircraft cockpits places high demands on the colour vision of pilots. The present study investigates colour vision changes upon acute exposure to hypobaric hypoxia. The digital Waggoner Computerized Color Vision Test and the Waggoner D-15 were performed by 54 healthy volunteers in a decompression chamber.

Redefining diagnostic parameters: the role of overvaluation of shape and weight in binge-eating disorder: a systematic review.

Introduction: Overvaluation of shape and weight is a critical component in understanding and diagnosing eating disorders. While the transdiagnostic model states that overvaluation of shape and weight is the core pathology of all eating disorders, this concept is not a criterion for binge-eating disorder. The lack of recognition of overvaluation of shape and weight may lead to overlooking, and consequently failure to address this construct during treatment.

Chest pain in a multi-ethnic population: A community-based study on sex differences in chest pain prevalence and care contacts.

Objective: While chest pain is a common symptom, its prevalence among women and men across ethnic groups is unknown. Moreover, how chest pain is associated with general practitioner (GP) and cardiologist visits in women and men across ethnic groups, remains to be determined.

Design: We used baseline data on 12423 women and 9071 men from the multi-ethnic HELIUS cohort (Amsterdam, the Netherlands; 2011-2015).

An Overview of Patient-reported Outcomes for Men with Prostate Cancer: Results from the PIONEER Consortium.

Background And Objective: Patient-reported outcome measures (PROMs) are increasingly being used to capture the patients' perspective of their functional status and quality of life (QoL). Big data can help us better understand patient-reported outcomes (PROs). Using prospectively collected data from the Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) consortium, we aimed to describe the functional status and QoL in men with prostate cancer (PCa) treated with active surveillance (AS), radical prostatectomy (RP), and radiotherapy (RT), and to demonstrate the applicability of PROM data on a large scale and at a European level.

Learning to fear novel stimuli by observing others in the social affordance framework.

Fear responses to novel stimuli can be learned directly, through personal experiences (Fear Conditioning, FC), or indirectly, by observing conspecific reactions to a stimulus (Social Fear Learning, SFL). Although substantial knowledge exists about FC and SFL in humans and other species, they are typically conceived as mechanisms that engage separate neural networks and operate at different levels of complexity. Here, we propose a broader framework that links these two fear learning modes by supporting the view that social signals may act as unconditioned stimuli during SFL.

Getting back on track after treatment of cancer: A qualitative interview study of cancer survivors' experiences.

Objective: An increasing number of people resumes life after cancer treatment. Although the (long-term) side-effects of cancer and its treatment can be significant, less is known about the impact on cancer survivors' participation in daily life. The aim of this study was to explore the common experiences of cancer survivors in resuming life after treatment.

Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder.

Importance: Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the candidate genetic variants included in the algorithm has not been independently demonstrated.

Objective: To assess the utility of 15 genetic variants from an algorithm intended to predict OUD risk.

Voxel-based lesion symptom mapping localizes residual visual function in hemianopia.

Damage to the primary visual cortex (V1) results in visual field deficits on the contralateral side of the world corresponding to the damaged region. Patients with such loss nonetheless show varying residual vision within this apparently blind region, with the neural mechanisms underlying this ability obscured by small study populations. We identified lesions on structural scans from 39 patients (12 female) with hemianopia and occipital lobe damage.

Physical Activity, Sleep and Eating in Young People With Borderline Personality Disorder.

Previous research suggests a connection between borderline personality disorder (BPD) and somatic comorbidities, underscoring the importance of lifestyle and health-related behaviour (LHRB) in the emergence of BPD. We investigated LHRBs-physical activity, sleeping and overeating-among young people at different BPD stages compared to a matched community sample. Furthermore, we explored whether problematic LHRBs intensify in later BPD stages.

Predicting clinical outcomes in a blended care intervention for early psychosis: Acceptance and Commitment Therapy in Daily-Life (ACT-DL).

ACT in Daily Life (ACT-DL) is a blended-care Ecological Momentary Intervention that extends ACT into the daily life of individuals, improving psychotic distress, negative symptoms, and global functioning. However, it remains unclear whether ACT-DL works equally for everyone. We investigated whether moderators (i.

"I am sick, but that's not all that I am": patient perspectives on psychological adaptation over time to inborn errors of immunity.

Inborn errors of immunity (IEI) are rare heritable disorders of the immune system predisposing to atypical infections, autoimmunity, inflammation, and risk of malignancy. Adaptation is the process of incorporating stressful experiences into one's life; these experiences may include onset of illness, receiving a diagnosis, or suffering without a diagnosis. Poor adaptation is linked to adverse outcomes including psychiatric comorbidities and decreased well-being.

The Associations Between Temperament and Self-Oriented, Other-Oriented, and Dual-Harmful Behaviors in Emerging Adults.

Self- and other-oriented harmful behaviors are common among emerging adults. Individuals who engage in both forms of behavior, termed dual-harm, experience more adverse outcomes in comparison to individuals who engage in either. This study examines temperamental traits, defined as reactive and regulative temperament, as transdiagnostic factors underlying engagement in self-oriented, other-oriented, and dual-harmful behaviors.

The Impact of Chemotherapy and Body Mass Index on Cancer-Related Fatigue in Colon Cancer Patients: A PROFILES-Registry Study.

Background: Inflammation has been reported to drive cancer-related fatigue (CRF). As both obesity and chemotherapy promote inflammatory responses, obese cancer patients may be at risk of more severe CRF, especially when receiving chemotherapy.

Methods: We analysed data of 333 colon cancer patients from four hospitals in the Netherlands (data derived from the PROCORE study).

Seeing your child in pain: Parent empathy in the context of their child's chronic pain.

Observing your child in pain is inherently distressing. In the context of chronic pain, caregiver responses can powerfully impact child pain-related functioning. The Parent Empathy in the Context of Pain model postulates that parent empathic distress may hinder adaptive responses to child pain, thus playing a key role in the link between parent responses and child functioning.

Talking Cancer-Cancer Talking: A Linguistic and Thematic Analysis of Patient Narratives.

To explore "the lived experience" of patients with cancer through narratives, in-depth interviews with 20 patients were conducted in the patients' homes-"at the kitchen table." Interviews were audio-recorded, transcribed, and analyzed following the Linguistic Inquiry and Word Count (LIWC) methodology. Thematic Analysis was used to explore themes in the narratives.

Limited consensus on what climate anxiety is: Insights from content overlap analysis on 12 questionnaires.

Climate anxiety is a phenomenon that is gaining importance due to the general public's increased awareness of the worsening climate crisis. At present, climate anxiety is not operationalized consistently across the existing literature. It is important to gain more consensus on the definition and operationalization of climate anxiety to facilitate reliable and generalizable research and to further develop interventions.

Muscle atrophy and organ enlargement associated with quality of life during systemic therapy for melanoma: findings from an AI-based body composition analysis.

Introduction: Health-related quality of life (HRQoL) is emerging as an endpoint, adjunct to survival, in cancer treatment. For this reason, the European Organization for Research and Treatment of Cancer (EORTC) has developed standardized quality-of-life questionnaires to collect patient-reported outcome measurement (PROM), which so far have been widely used in clinical trials to evaluate the impact of new drugs on cancer patients. However, while these questionnaires comprehensively describe patient functions, little is known about their association with patient characteristics.

Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood.

Objectives: We investigated whether empirically derived childhood obesity phenotypes were differentially associated with risk of hypertension in young adulthood, and whether these associations differed by sex.

Methods: Data came from 11,404 participants in the Growing Up Today Study, a prospective cohort study in the US established in 1996. We used a childhood obesity phenotype variable that was previously empirically derived using latent class analysis.

Validating the Q1.6 Inguinal Hernia application using prospective data from a randomised clinical trial.

Purpose: The Q1.6 Inguinal Hernia application remotely and continuously collects patient-reported outcomes from inguinal hernia patients. Previous research has explored its technical, legal, and ethical aspects, along with face, content, and construct validity assessments.