2 results match your criteria: "Department of Medical Oncology Beijing Tsinghua Changgung Hospital Beijing China.[Affiliation]"
Liquid-liquid phase separation (LLPS) has emerged as a pivotal biological phenomenon involved in various cellular processes, including the formation of membrane-less organelles and the regulation of biomolecular condensates through precise spatiotemporal coordination of signaling pathways in cells. Dysregulation of LLPSs results in aberrant biomolecular condensates, which are widely implicated in tumorigenesis and cancer progression. Here, we comprehensively summarize the multifaceted roles of LLPS in tumor biology from the perspective of cancer hallmarks, including genomic stability, metabolic reprogramming progression, ferroptosis, and metastasis, to unveil the intricate mechanisms by which LLPS occurs in tumorigenesis.
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- * A case study discusses a 45-year-old man whose NEN was initially revealed through chest pain, leading to successful surgical removal of the tumor.
- * Follow-up treatment involved radiation therapy and systemic medication, resulting in no recurrence or metastasis after 6 months, demonstrating the effectiveness of comprehensive treatment options.