Influence of acupuncture intensity on analgesic effects in AA rat models.

Objective: To investigate the influence of acupuncture lifting-thrusting frequency and amplitude on the analgesic effects, and its correlation with mast cell degranulation.

Methods: Acute adjuvant arthritis (AA) rat models were employed. Robot-arm aided lifting-thrusting acupuncture therapy was conducted with various frequencies (ranging from 0.

[Pediatric surgery for middle ear cholesteatoma: analysis of 47 cases].

The clinical data of 47 children (52 ears) with middle ear cholesteatoma at Eye & ENT Hospital, Fudan University from January 2021 to February 2024 were prospectively collected. There were 30 males and 17 females, with a mean age of (8.5±2.

[Expert consensus on endoscopic surgery for the pediatric middle ear cholesteatoma based on the classification of cholesteatoma location].

Pediatric middle ear cholesteatoma is an aggressive keratotic lesion caused by abnormal proliferation of keratinised squamous epithelium in the temporal bone, with the characteristics of high postoperative recurrence rate, poor hearing effect and poor quality of life. Endoscopic surgery is able to deal with the majority of pediatric middle ear cholesteatoma cases with the features of minimal trauma and wide surgical field. However, endoscopic surgical treatment still has problems in standardization.

[The path to advancement in endoscopic ear surgery].

Endoscopic ear surgery is currently widely applied in middle ear and lateral skull base procedures, driving the development of ear surgery towards minimally invasive approaches and function preservation. Endoscopic techniques offer many advantages. However, the learning curve is relatively steep, requiring surgeons to overcome challenges such as single-handed operation and a lack of spatial awareness.

Differences in anterior ocular biometric characteristics among 6-year-old children with different myopic shift rates: A 2-year longitudinal study.

Background: To investigate longitudinal changes in anterior ocular features during slow and fast myopic shift in 6-year-old children.

Methods: In total, 242 eyes of first-year primary school children in Shanghai, China, were included in this study. All children underwent an initial examination and were subsequently followed-up for two years.

Effective prism diopter for strabismus measurement: Conversion from anterior Prentice position to posterior parallel position and from glass prism to acrylic prism.

Purpose: In clinical ophthalmology, prisms, commonly made of glass, are labeled based on the prism diopter (PD) value measured in the anterior Prentice position. However, they are often used in the posterior parallel position for practicality, causing a discrepancy between labeled and effective PD. This study proposes a conversion tool to address this issue.

Mastery Learning Guided by Artificial Intelligence Is Superior to Directed Self-Regulated Learning in Flexible Bronchoscopy Training: An RCT.

Introduction: Simulation-based training has proven effective for learning flexible bronchoscopy. However, no studies have tested the efficacy of training toward established proficiency criteria, i.e.

Seven-year refractive outcomes comparing small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis for myopia and myopic astigmatism.

This study aimed to compare the seven-year refractive outcomes of small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for correction of myopia and myopic astigmatism. This retrospective cohort study included 97 eyes of 53 patients who had undergone SMILE or FS-LASIK for myopia seven years prior. Measured parameters included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and manifest refraction.

A genetic investigation in five Chinese families with keratoconus.

Background: This study investigated the genetic characteristics of five Chinese families with keratoconus (KC).

Methods: In the five families affected by KC, medical records, clinical observations, and blood samples were collected from all individuals. All KC family members ( = 20) underwent both whole exome sequencing of genomic DNA and Sanger sequencing to confirm the variants.

Mild Phenotypes of Gyrate Atrophy in a Heterozygous Carrier with One Variant Allele of .

This study aimed to identify whether gyrate atrophy of the choroid and retina (GACR) heterozygous individuals have possible clinical manifestations and to explore the potential pathogenic mechanism. In this retrospective study, we surveyed a two-generation pedigree of an individual diagnosed with GACR. Two family members underwent ophthalmological, hematologic, and genetic tests.

A novel variant in the keratin 12 gene in a four-generation Chinese family with high myopia.

Background: High myopia is a major cause of visual impairment, and genetic factors play crucial roles in the pathogenesis. We performed this study to identify candidate genes for the development of high myopia in a four-generation Chinese family with myopia.

Methods: All family members with myopia and 100 healthy participants were included in this study.

Physiologically Based Pharmacokinetic Modeling and Clinical Extrapolation for Topical Application of Pilocarpine on Eyelids: A Comprehensive Study.

Exploiting a convenient and highly bioavailable ocular drug delivery approach is currently one of the hotspots in the pharmaceutical industry. Eyelid topical application is seen to be a valuable strategy in the treatment of chronic ocular diseases. To further elucidate the feasibility of eyelid topical administration as an alternative route for ocular drug delivery, pharmacokinetic and pharmacodynamic studies of pilocarpine were conducted in rabbits.

Correlation analysis of angles κ and α with the refraction and anterior segment parameters in children.

Aim: To investigate the correlation of angles α and κ with the refractive and biological parameters in children.

Methods: This case-series study included 438 eyes of 219 children (males/females = 105/114, age: 3-15 years). Ocular biometric parameters, including axial length, corneal radius of curvature (CR), white-to-white distance (WTW), angle κ and angle α, were measured using IOL Master 700; auto-refraction were assessed under cycloplegia.

Genetic investigation in a four-generation Chinese family with congenital fibrosis of extraocular muscles and keratoconus.

Here, we have reported the genetic and clinical characteristics of four generations of a family patient from China with congenital fibrosis of extraocular muscles 1 (CFEOM1) and keratoconus (KC). The history of diseases, clinical observations, and blood samples of all family members were collected. A total of 100 healthy participants were recruited as normal controls.

Detection of SARS-CoV-2 virus in middle ear effusions and its association with otitis media with effusion.

A large-scale outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) occurred in Shanghai, China, in early December 2022. To study the incidence and characteristics of otitis media with effusion (OME) complicating SARS-CoV-2, we collected 267 middle ear effusion (MEE) samples and 172 nasopharyngeal (NP) swabs from patients. The SARS-CoV-2 virus was detected by RT-PCR targeting.

Variants in the gene in families with Brittle cornea syndrome and keratoconus.

Background: Brittle cornea syndrome 1 (BCS1) is a rare autosomal recessive disorder characterized by corneal and sclera thinning and fragility that is caused by zinc finger protein 469 () gene mutation. Keratoconus is another disease related to corneal thinning. Several reports have linked variants and keratoconus.

Anatomical studies and early results on endoscopic transoral medial pterygomandibular fold approach to salvage retropharyngeal lymphadenectomy in nasopharyngeal carcinoma.

Objective: Retropharyngeal lymphadenectomy is challenging. This study investigated a minimally invasive approach to salvage retropharyngeal lymphadenectomy in patients with nasopharyngeal carcinoma.

Methods: An anatomical study of four fresh cadaveric heads was conducted to demonstrate the relevant details of retropharyngeal lymphadenectomy using the endoscopic transoral medial pterygomandibular fold approach.