8 results match your criteria: "Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden.[Affiliation]"
Caplacizumab reduces the need for therapeutic plasma exchange (TPE) during treatment for thrombotic thrombocytopenic purpura (TTP), associates with fewer required TPE, and shortens hospital stay. It is therefore recommended as part of standard care. However, the treatment effects on hemostasis may complicate initial management.
View Article and Find Full Text PDFNormal Fasting Triglyceride Levels and Incident Hypertension in Community-Dwelling Individuals Without Metabolic Syndrome.
J Am Heart Assoc
August 2023
Division of Clinical Chemistry, Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden.
Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.
Clin Transl Immunology
July 2021
Article Synopsis
- * Researchers analyzed over 100 SARS-CoV-2 protein representations and selected three key antigens from the spike glycoprotein and nucleocapsid protein for further testing on samples from COVID-19 patients and uninfected controls.
- * The final assay achieved impressive accuracy, with sensitivities ranging from 99.1% to 99.7% and specificities from 95.7% to 100%, especially when using two antigens together, demonstrating the assay's potential for reliable COVID-19 detection.
SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.
Clin Transl Immunology
July 2021
Department of Medicine Huddinge, Center for Infectious Medicine Karolinska Institutet Stockholm Sweden.
Article Synopsis
- The study aimed to understand how the immune system responds to SARS-CoV-2 in COVID-19 patients, focusing on the development and durability of both humoral (antibody-mediated) and cellular immunity.
- Researchers tracked hospitalized patients from the acute phase of COVID-19 through their recovery at 5 and 9 months, employing various immune response assessments like flow cytometry and serological assays.
- Results indicated that while antibody levels decrease over time, there is still a presence of neutralizing antibodies and strong memory B and T cell responses, suggesting long-term immune protection against reinfection.
Background We recently showed that, in patients with heart failure, lower high-density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow-up study, we suggested that this association could be partly explained by HDL proteome composition. However, whether the emerging concept of HDL function contributes to the prognosis of patients with heart failure has not been addressed.
View Article and Find Full Text PDFBackground Morphine administration is a strong predictor of delayed onset of action of orally administered ticagrelor in patients with ST-segment-elevation myocardial infarction, likely because of impaired gastrointestinal motility. The aim of this study was to evaluate whether the peripheral opioid antagonist methylnaltrexone could improve pharmacodynamics and pharmacokinetics of orally administered ticagrelor in patients with ST-segment-elevation myocardial infarction receiving morphine. Methods and Results The MOVEMENT (Methylnaltrexone to Improve Platelet Inhibition of Ticagrelor in Morphine-Treated Patients With ST-Segment Elevation Myocardial Infarction) trial was a multicenter, prospective, randomized, controlled trial in patients with ST-segment-elevation myocardial infarction treated with morphine and ticagrelor.
View Article and Find Full Text PDFEzetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients.
J Am Heart Assoc
December 2018
4 Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme Karolinska University Hospital Stockholm Sweden.
Background In randomized trials (SHARP [Study of Heart and Renal Protection], IMPROVE -IT [Improved Reduction of Outcomes: Vytorin Efficacy International Trial]), combination of statin and ezetimibe resulted in additional reduction of cardiovascular events. The reduction was greater in patients with type 2 diabetes mellitus (T2 DM ), where elevated remnant cholesterol and high cardiovascular disease risk is characteristic. To evaluate possible causes behind these results, 40 patients eligible for cholecystectomy, randomized to simvastatin, ezetimibe, combined treatment (simvastatin+ezetimibe), or placebo treatment during 4 weeks before surgery, were studied.
View Article and Find Full Text PDFIntroduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
Methods: To explore the importance of cholesterol homeostasis for asthma, we investigated the contribution of LXR activity in an ovalbumin- and a house dust mite-driven eosinophilic asthma mouse model.