1 results match your criteria: "Department of Joint Surgery Guangzhou Hospital of Integrated Traditional and Western Medicine[Affiliation]"
Synergistic Effects of Icariin and Extracellular Vesicles Derived from Rabbit Synovial Membrane-Derived Mesenchymal Stem Cells on Osteochondral Repair via the Wnt/-Catenin Pathway.
Anal Cell Pathol (Amst)
July 2024
Department of Joint Surgery Guangzhou Hospital of Integrated Traditional and Western Medicine, Guangzhou, China.
Article Synopsis
- Osteochondral defects (OCDs) lead to joint pain and dysfunction, and icariin (ICA) has potential in repairing cartilage damage, though its mechanism is not well understood.
- This study examined the effects of ICA and extracellular vesicles from rabbit stem cells on repairing OCDs by analyzing various cellular and molecular factors.
- The results indicated that combined treatment with ICA and stem cell-derived extracellular vesicles significantly enhanced cell proliferation and chondrogenic marker expression, suggesting a synergistic effect that may involve the Wnt/β-catenin signaling pathway, promoting cartilage repair in joint defects.*