3 results match your criteria: "Department of Immunology at National Jewish Medical and Research Center[Affiliation]"
J Clin Immunol
March 2007
Department of Immunology at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA.
Lymphocytes expressing gammadelta T cell receptors (TCR) constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. The gammadelta TCRs share structural features with adaptive receptors and peripheral selection of gammadelta T cells occurs. Nevertheless, their specificities may be primarily directed at self-determinants, and the responses of gammadelta T cells exhibit innate characteristics.
View Article and Find Full Text PDFScand J Immunol
September 2003
Department of Immunology at National Jewish Medical and Research Center, Denver, CO 80206, USA.
Hybridomas expressing murine gammadelta T-cell receptors were found to produce cytokines in response to cardiolipin (CL) and structurally related anionic phospholipids. This response required serum at concentrations related to the amount of CL in cultures. The purified serum factor, beta2-glycoprotein 1 (beta2-GP1) (apolipoprotein H), supported the CL response alone, whereas several other serum proteins and ovalbumin did not.
View Article and Find Full Text PDFInt Arch Allergy Immunol
July 2001
Department of Immunology at National Jewish Medical and Research Center, Denver, Colo., USA.
Airway responsiveness (AR) is determined by complex mechanisms reflecting lung responses to airborne stimuli. Murine studies have identified a number of potential factors modulating AR and thus have contributed to the current understanding of these mechanisms. In allergic inflammation, immune cells, in particular alphabeta T cells, have emerged as important contributors to increased AR.
View Article and Find Full Text PDF