2 results match your criteria: "Department of Immunogenetics Institute of Hematology and Transfusion Medicine[Affiliation]"
Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
Int J Mol Sci
January 2019
Department of Transplantation Medicine, Nephrology, Internal Diseases, T. Orłowski Institute of Transplantation Medical University of Warsaw, 59 Nowogrodzka Street, 02-006 Warsaw, Poland.
Article Synopsis
- Cytomegalovirus (CMV) infection poses significant risks to kidney transplant recipients, leading to serious complications and potential mortality.
- Research involving 138 transplant recipients revealed that specific KIR genes and their ligands, along with factors like kidney function and timing of antiviral treatment, influence the likelihood of developing posttransplant CMV infection.
- The study highlights the importance of both genetic and environmental factors in determining susceptibility to CMV infection after kidney transplantation, emphasizing the role of KIR/HLA genotype in immunity against the virus.
Potential link between MHC-self-peptide presentation and hematopoiesis; the analysis of HLA-DR expression in CD34-positive cells and self-peptide presentation repertoires of MHC molecules associated with paroxysmal nocturnal hemoglobinuria.
Cell Biochem Biophys
April 2013
Department of Immunogenetics Institute of Hematology and Transfusion Medicine, 14 Indira Gandhi Street, 02-776, Warsaw, Poland.
The mechanisms of MHC allele associations with paroxysmal nocturnal hemoglobinuria (PNH) and its aplastic anemia subtype (AA/PNH) remain unclear. It might be dependent on MHC molecule functional properties, such as a scope and frequency of antigen sampling and presentation. For documented PNH-associated MHC alleles we analyzed current reference databases on MHC molecule-eluted peptide presentation repertoires and searched for a range of presented peptides.
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